PMID- 26229097
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1477-0393 (Electronic)
IS  - 0748-2337 (Linking)
VI  - 32
IP  - 11
DP  - 2016 Nov
TI  - Formaldehyde exposure inhibits the expression of mammalian target of rapamycin in 
      rat testis.
PG  - 1882-1890
LID - 10.1177/0748233715592992 [doi]
AB  - Formaldehyde (FA), a ubiquitous environmental pollutant, has long been suspected 
      of causing adverse male reproductive effects. However, the molecular and cellular 
      mechanisms underlying this phenomenon remain elusive. The overall aim of this 
      study is to clarify the role of mammalian target of rapamycin (mTOR) in male 
      reproductive injuries induced by FA exposure, by which we can further understand 
      the molecular mechanism of FA male reproductive toxicity. In this study, 
      immunohistochemistry, Western blotting, and reverse transcription polymerase 
      chain reaction analysis were used to detect the expression of mTOR molecule in 
      testicular tissues. We found that FA exposure inhibits the expression of mTOR in 
      a dose-dependent manner. Combined with our earlier finding, we found the 
      decreasing expression of mTOR in testicular tissue were consistent with the 
      changes of testicular structure and autophagy levels. In summary, our data 
      suggested that mTOR molecule might be involved in male reproductive injuries 
      induced by FA exposure.
FAU - Fang, Jing
AU  - Fang J
AD  - 1 Department of Gynecology and Obstetrics, First Affiliated Hospital, Medical 
      School, Xi'an Jiaotong University, Xi'an, China.
AD  - 2 Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 
      China.
AD  - 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, China.
FAU - Li, Dong-Hui
AU  - Li DH
AD  - 4 Department of Oncology, The People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Yu, Xiao-Qing
AU  - Yu XQ
AD  - 5 Department of Gynecology and Obstetrics, Kangfu Hospital of Shaanxi Province, 
      Xi'an, China.
FAU - Lv, Mo-Qi
AU  - Lv MQ
AD  - 2 Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 
      China.
AD  - 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, China.
FAU - Bai, Li-Zhi
AU  - Bai LZ
AD  - 2 Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 
      China.
AD  - 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, China.
FAU - Du, Liang-Zhi
AU  - Du LZ
AD  - 2 Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 
      China.
AD  - 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, China.
FAU - Zhou, Dang-Xia
AU  - Zhou DX
AD  - 2 Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 
      China.
AD  - 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20160710
PL  - England
TA  - Toxicol Ind Health
JT  - Toxicology and industrial health
JID - 8602702
OTO - NOTNLM
OT  - Formaldehyde
OT  - mammalian target of rapamycin (mTOR)
OT  - reproductive toxicity
OT  - testis
EDAT- 2015/08/01 06:00
MHDA- 2015/08/01 06:01
CRDT- 2015/08/01 06:00
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2015/08/01 06:01 [medline]
PHST- 2015/08/01 06:00 [entrez]
AID - 0748233715592992 [pii]
AID - 10.1177/0748233715592992 [doi]
PST - ppublish
SO  - Toxicol Ind Health. 2016 Nov;32(11):1882-1890. doi: 10.1177/0748233715592992. 
      Epub 2016 Jul 10.