PMID- 2623005
OWN - NLM
STAT- MEDLINE
DCOM- 19900326
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 34
IP  - 3
DP  - 1989 Nov
TI  - Caffeine ingested under natural conditions does not alter taste intensity.
PG  - 483-5
AB  - It has been reported that prolonged application of 10 micromolar (microM) 
      caffeine (CAF) to the dorsal surface of the tongue may markedly enhance the 
      perceived intensity of many taste stimuli, including NaCl and several 
      noncarbohydrate sweeteners. The present study investigated the effect of oral CAF 
      vs. placebo ingestion on perceived taste intensity. Ingestion of CAF (5.5 mg/kg) 
      raised median salivary CAF levels to 19.8 microM at 50 minutes post-dose, when 
      subjects evaluated the intensity of solutions of 5 noncarbohydrate sweeteners, 2 
      carbohydrate sweeteners, 2 bitter tastants, NaCl, citric acid, 2 odors, and a 
      tone. Taste solutions were prepared using either 1) deionized water or 2) 10 
      microM CAF as the medium, and all stimuli were rated for intensity on a 9-point 
      category scale. There was no effect of condition (CAF or placebo) or tastant 
      medium on any response measure. The results suggest that perceptions of taste 
      intensity are not appreciably altered under natural conditions of CAF ingestion 
      and subsequent lingual adaptation to microM levels of CAF in saliva.
FAU - Mela, D J
AU  - Mela DJ
AD  - Monell Chemical Senses Center, Philadelphia, PA 19104.
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Caffeine/*administration & dosage
MH  - Female
MH  - Humans
MH  - Male
MH  - Sensory Thresholds/*drug effects
MH  - Taste/*drug effects
MH  - Tongue/drug effects/*physiology
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 0091-3057(89)90544-3 [pii]
AID - 10.1016/0091-3057(89)90544-3 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1989 Nov;34(3):483-5. doi: 10.1016/0091-3057(89)90544-3.