PMID- 26230366 OWN - NLM STAT- MEDLINE DCOM- 20160923 LR - 20151216 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 18 IP - 8 DP - 2015 TI - BDNF levels in adipose tissue and hypothalamus were reduced in mice with MSG-induced obesity. PG - 376-82 LID - 10.1179/1476830515Y.0000000039 [doi] AB - OBJECTIVES: To observe the expression of brain-derived neurotrophic factor (BDNF) in hypothalamic and adipose tissue in mice with monosodium glutamate (MSG)-induced obesity. METHODS: The effects of hypothalamic lesions, specifically arcuate nucleus (ARC) lesions, induced by MSG injection were studied in male ICR mice at the neonatal stage. The following parameters were compared: body weight, body length, Lee's index, food intake, body temperature, fat weight, and levels of total cholesterol (CHOL), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and blood glucose (GLU). The BDNF expression levels in hypothalamic and adipose tissue were measured using western blotting. Results Compared with the control group, the model group body had significantly higher weight, Lee's index, food intake, fat weight, CHOL, TG, LDL, HDL, and GLU levels. BDNF expression levels in hypothalamic and adipose tissue were markedly down-regulated in the model group. DISCUSSION: BDNF may be closely associated with MSG-induced hypothalamic obesity. FAU - Jin, Yong Jun AU - Jin YJ FAU - Cao, Peng Juan AU - Cao PJ FAU - Bian, Wei Hua AU - Bian WH FAU - Li, Ming E AU - Li ME FAU - Zhou, Rong AU - Zhou R FAU - Zhang, Ling Yun AU - Zhang LY FAU - Yang, Mei Zi AU - Yang MZ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150731 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 RN - 0 (Blood Glucose) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cholesterol, HDL) RN - 0 (Cholesterol, LDL) RN - 0 (Triglycerides) RN - W81N5U6R6U (Sodium Glutamate) SB - IM MH - Adipose Tissue/*metabolism MH - Animals MH - Arcuate Nucleus of Hypothalamus/metabolism MH - Blood Glucose/metabolism MH - Body Weight MH - Brain-Derived Neurotrophic Factor/genetics/*metabolism MH - Cholesterol, HDL/blood MH - Cholesterol, LDL/blood MH - Diet MH - Down-Regulation MH - Hypothalamus/*metabolism MH - Male MH - Mice MH - Mice, Inbred ICR MH - Obesity/chemically induced/*physiopathology MH - Organ Size MH - Sodium Glutamate MH - Triglycerides/blood OTO - NOTNLM OT - Brain-derived neurotrophic factor (BDNF) OT - Hypothalamic obesity OT - Monosodium glutamate (MSG) OT - mouse model. EDAT- 2015/08/01 06:00 MHDA- 2016/09/24 06:00 CRDT- 2015/08/01 06:00 PHST- 2015/08/01 06:00 [entrez] PHST- 2015/08/01 06:00 [pubmed] PHST- 2016/09/24 06:00 [medline] AID - 10.1179/1476830515Y.0000000039 [doi] PST - ppublish SO - Nutr Neurosci. 2015;18(8):376-82. doi: 10.1179/1476830515Y.0000000039. Epub 2015 Jul 31.