PMID- 26230582
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20201215
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - The Adaptive Change of HLA-DRB1 Allele Frequencies Caused by Natural Selection in 
      a Mongolian Population That Migrated to the South of China.
PG  - e0134334
LID - 10.1371/journal.pone.0134334 [doi]
LID - e0134334
AB  - Pathogen-driven balancing selection determines the richness of human leukocyte 
      antigen (HLA) alleles. Changes in the pathogen spectrum may cause corresponding 
      changes in HLA loci. Approximately 700 years ago, a Mongolian population moved 
      from the north of China to the Yunnan region in the south of China. The pathogen 
      spectrum in the south of China differs from that in the north. In this study, 
      changes in the HLA genes in the Yunnan Mongolian population, as well as the 
      underlying mechanism, were investigated. A sequence-based typing method (SBT) was 
      used to genotype HLA-DRB1 in 470 individuals from two Mongolian populations and 
      another five ethnic groups. Meanwhile, 10 autosomal short tandem repeats (STRs) 
      were genotyped to assess the influence of genetic background on HLA-DRB1 
      frequencies. The frequencies of certain alleles changed significantly in the 
      Mongolian population that migrated to Yunnan. For example, DRB1*12:02:01 
      increased from 6.1% to 35.4%. STR analysis excluded the possibility of a recent 
      bottleneck and indicated that 50% of the genetic consistency between northern and 
      southern Mongolians; Tajima's D value for HLA-DRB1 exon2 and dN/dS analysis 
      showed that the HLA-DRB1 genes in both Mongolian populations were under balancing 
      selection. However, the sites under natural selection changed. We proposed that 
      the dramatically change of HLA frequencies in southern Mongolian was caused by a 
      combination of inter-population gene flow and natural selection. Certain diseases 
      specific to the south of China, such as malaria, may be the driving force behind 
      the enhanced DRB1*12:02:01 frequency.
FAU - Sun, Hao
AU  - Sun H
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Yang, Zhaoqing
AU  - Yang Z
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Lin, Keqin
AU  - Lin K
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Liu, Shuyuan
AU  - Liu S
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Huang, Kai
AU  - Huang K
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Wang, Xiuyun
AU  - Wang X
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Chu, Jiayou
AU  - Chu J
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
FAU - Huang, Xiaoqin
AU  - Huang X
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Kunming 650118, China.
LA  - eng
GR  - K99 AA021802/AA/NIAAA NIH HHS/United States
GR  - R00 AA021802/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150731
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - China
MH  - *Gene Frequency
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Microsatellite Repeats
MH  - Mongolia
MH  - *Selection, Genetic
PMC - PMC4521750
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/08/01 06:00
MHDA- 2016/05/03 06:00
PMCR- 2015/07/31
CRDT- 2015/08/01 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2015/07/31 00:00 [pmc-release]
AID - PONE-D-14-50684 [pii]
AID - 10.1371/journal.pone.0134334 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 31;10(7):e0134334. doi: 10.1371/journal.pone.0134334. 
      eCollection 2015.