PMID- 26230993
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20201215
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head 
      Structure in Early Experimental Glaucoma.
PG  - e0134223
LID - 10.1371/journal.pone.0134223 [doi]
LID - e0134223
AB  - The lamina cribrosa likely plays an important role in retinal ganglion cell axon 
      injury in glaucoma. We sought to (1) better understand optic nerve head (ONH) 
      structure and anterior lamina cribrosa surface (ALCS) microarchitecture between 
      fellow eyes of living, normal non-human primates and (2) characterize the 
      time-course of in vivo structural changes in the ONH, ALCS microarchitecture, and 
      retinal nerve fiber layer thickness (RNFLT) in non-human primate eyes with early 
      experimental glaucoma (EG). Spectral domain optical coherence tomography (SDOCT) 
      images of the ONH were acquired cross-sectionally in six bilaterally normal 
      rhesus monkeys, and before and approximately every two weeks after inducing 
      unilateral EG in seven rhesus monkeys. ONH parameters and RNFLT were quantified 
      from segmented SDOCT images. Mean ALCS pore area, elongation and nearest neighbor 
      distance (NND) were quantified globally, in sectors and regionally from adaptive 
      optics scanning laser ophthalmoscope images. In bilaterally normal monkeys, ONH 
      parameters were similar between fellow eyes with few inter-eye differences in 
      ALCS pore parameters. In EG monkeys, an increase in mean ALCS Depth (ALCSD) was 
      the first structural change measured in 6 of 7 EG eyes. A decrease in mean 
      minimum rim width (MRW) simultaneously accompanied this early change in 4 of 6 EG 
      eyes and was the first structural change in the 7th EG eye. Mean ALCS pore 
      parameters were among the first or second changes measured in 4 EG eyes. Mean 
      ALCS pore area and NND increased in superotemporal and temporal sectors and in 
      central and peripheral regions at the first time-point of change in ALCS pore 
      geometry. RNFLT and/or mean ALCS radius of curvature were typically the last 
      parameters to initially change. Survival analyses found mean ALCSD was the only 
      parameter to significantly show an initial change prior to the first measured 
      loss in RNFLT across EG eyes.
FAU - Ivers, Kevin M
AU  - Ivers KM
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Sredar, Nripun
AU  - Sredar N
AD  - Department of Computer Science, University of Houston, Houston, Texas, United 
      States of America.
FAU - Patel, Nimesh B
AU  - Patel NB
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Rajagopalan, Lakshmi
AU  - Rajagopalan L
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Queener, Hope M
AU  - Queener HM
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Twa, Michael D
AU  - Twa MD
AD  - School of Optometry, University of Alabama, Birmingham, Birmingham, Alabama, 
      United States of America.
FAU - Harwerth, Ronald S
AU  - Harwerth RS
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Porter, Jason
AU  - Porter J
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
LA  - eng
GR  - P30 EY007551/EY/NEI NIH HHS/United States
GR  - K23 EY021761/EY/NEI NIH HHS/United States
GR  - R01 EY001139/EY/NEI NIH HHS/United States
GR  - R01 EY022362/EY/NEI NIH HHS/United States
GR  - R01 EY021783/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150731
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Glaucoma/*pathology
MH  - Macaca mulatta
MH  - Optic Disk/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
PMC - PMC4521723
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/08/01 06:00
MHDA- 2016/05/03 06:00
PMCR- 2015/07/31
CRDT- 2015/08/01 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2015/07/31 00:00 [pmc-release]
AID - PONE-D-14-55680 [pii]
AID - 10.1371/journal.pone.0134223 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 31;10(7):e0134223. doi: 10.1371/journal.pone.0134223. 
      eCollection 2015.