PMID- 26231803
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20161126
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 29
IP  - 8
DP  - 2015 Nov-Dec
TI  - Can increased visceral adiposity without body weight changes accelerate carotid 
      atherosclerosis in South Korean participants with type 2 diabetes?
PG  - 1085-91
LID - S1056-8727(15)00235-4 [pii]
LID - 10.1016/j.jdiacomp.2015.06.007 [doi]
AB  - AIMS: Type 2 diabetes mellitus (T2DM) and visceral obesity are associated with 
      each other and with cardiovascular diseases. We determined whether increased 
      visceral adiposity without weight gain was associated with sex-specific 
      accelerated carotid atherosclerosis in South Koreans with T2DM. METHODS: From 
      2003 to 2012, we recruited 280 participants with T2DM for the Seoul Metabolic 
      Syndrome cohort who had body weight, visceral fat thickness (VFT), and carotid 
      intima-media thickness (CIMT) measured at intervals of 2years. According to VFT 
      change, sex-specific quartiles of clinical characteristics and changes of CIMT 
      were determined. Logistic regression models predicted the odds of the progression 
      of CIMTs in each quartile. RESULTS: During 2years of observation, VFTs fell by 
      5.2+/-13.5mm in men (P<0.001) and 3.4+/-10.5mm in women (P<0.001). Progression of 
      CIMT was only significant for women's maximal CIMT (0.031+/-0.145mm, P=0.012), 
      while significant improvements in HbA1c were found (0.9%; P<0.001 in both sexes). 
      There were no significant differences in clinical characteristics, or in 
      progression of CIMT in men or women according to 2-year quartiles of VFT change. 
      CONCLUSIONS: Our results do not suggest that increased visceral adiposity without 
      body weight changes impacts the CIMT progression in South Korean men or women 
      with T2DM.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kim, Chul Sik
AU  - Kim CS
AD  - Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, 
      Korea; Department of Family Medicine and Public Health, University of California 
      San Diego, La Jolla, CA, U.S.
FAU - Kim, Soo-Kyung
AU  - Kim SK
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 
      Seongnam, Korea.
FAU - Araneta, Maria Rosario G
AU  - Araneta MR
AD  - Department of Family Medicine and Public Health, University of California San 
      Diego, La Jolla, CA, U.S.
FAU - Lee, Eun Jig
AU  - Lee EJ
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 
      Korea. Electronic address: EJLEE423@yuhs.ac.
FAU - Barrett-Connor, Elizabeth
AU  - Barrett-Connor E
AD  - Department of Family Medicine and Public Health, University of California San 
      Diego, La Jolla, CA, U.S.. Electronic address: ebarrettconnor@ucsd.edu.
FAU - Huh, Kab Bum
AU  - Huh KB
AD  - Huh's Diabetes Center and the 21st Century Diabetes and Vascular Research 
      Institute, Seoul, Korea. Electronic address: huh7181827@hanmail.net.
LA  - eng
GR  - AG028507/AG/NIA NIH HHS/United States
GR  - AG07181/AG/NIA NIH HHS/United States
GR  - DK31801/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150619
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - *Adiposity
MH  - Aged
MH  - Body Mass Index
MH  - Carotid Artery Diseases/*complications/diagnostic 
      imaging/epidemiology/physiopathology
MH  - Carotid Intima-Media Thickness
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/diagnostic imaging/*epidemiology/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Hospitals, Special
MH  - Hospitals, Urban
MH  - Humans
MH  - Insulin Resistance
MH  - Intra-Abdominal Fat/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/*complications/metabolism/pathology
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Waist Circumference
OTO - NOTNLM
OT  - Carotid atherosclerosis
OT  - Carotid intima-media thickness
OT  - Obesity
OT  - Type 2 diabetes mellitus
OT  - Visceral fat thickness
EDAT- 2015/08/02 06:00
MHDA- 2016/09/13 06:00
CRDT- 2015/08/02 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/06/10 00:00 [revised]
PHST- 2015/06/12 00:00 [accepted]
PHST- 2015/08/02 06:00 [entrez]
PHST- 2015/08/02 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S1056-8727(15)00235-4 [pii]
AID - 10.1016/j.jdiacomp.2015.06.007 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2015 Nov-Dec;29(8):1085-91. doi: 
      10.1016/j.jdiacomp.2015.06.007. Epub 2015 Jun 19.