PMID- 26231904
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151008
LR  - 20150803
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 885
DP  - 2015 Jul 23
TI  - Determination of organophosphate flame retardants and plasticizers in lipid-rich 
      matrices using dispersive solid-phase extraction as a sample cleanup step and 
      ultra-high performance liquid chromatography with atmospheric pressure chemical 
      ionization mass spectrometry.
PG  - 183-90
LID - S0003-2670(15)00745-X [pii]
LID - 10.1016/j.aca.2015.05.024 [doi]
AB  - A fast, robust and highly sensitive analysis method for determination of trace 
      levels of organophosphate ester (OPE) flame retardants and plasticizers in 
      lipid-rich samples was presently developed, and based on ultra-high performance 
      liquid chromatography-tandem mass spectrometry coupled to a positive atmospheric 
      pressure chemical ionization source (UHPLC-MS/MS-APCI(+)). The target OPEs in the 
      sample were extracted from the biota samples, such as egg and liver, by 
      ultrasonic extraction, and cleaned up further by dispersive solid phase 
      extraction (d-ESP). As a result, background contamination was largely reduced. 
      Different dispersive ESP sorbents were tested and primary secondary amine (PSA) 
      bonded silica sorbents showed the best recoveries for these target OPEs. The 
      recoveries obtained were in the range 54-113% (RSD<17%), with method limits of 
      quantification (MLOQs) ranging between 0.06 and 0.29ng/g in egg, and 0.05 and 
      0.50ng/g w.w. in liver sample. The matrix effects (MEs) associated with using 
      APCI(+) and ESI(+) sources were investigated. APCI(+) showed much less ion 
      suppression than ESI(+) for the determination of these OPEs. For egg and liver 
      samples, the APCI(+) ME values ranged from 40% to 94%, while ESI(+) ME values 
      ranged from 0% to 36%. Although APCI(+) was used for the determination of OPEs, 
      the ionization mechanism might mainly be a thermospray ionization process. This 
      UHPLC-MS/MS-APCI(+) method showed good response linearity for calibration 
      (R2>0.99). The proposed method was applied to real environmental bird egg and 
      fish samples, where several OPE were quantifiable and different OPE patterns was 
      observed between samples.
CI  - Crown Copyright (c) 2015. Published by Elsevier B.V. All rights reserved.
FAU - Chu, Shaogang
AU  - Chu S
AD  - Wildlife and Landscape Science Directorate, Science and Technology Branch, 
      Environment Canada, National Wildlife Research Centre, Carleton University, 1125, 
      Colonel By Dr. (Raven Road), Ottawa, ON K1A 0H3, Canada. Electronic address: 
      shaogang.chu@ec.gc.ca.
FAU - Letcher, Robert J
AU  - Letcher RJ
AD  - Wildlife and Landscape Science Directorate, Science and Technology Branch, 
      Environment Canada, National Wildlife Research Centre, Carleton University, 1125, 
      Colonel By Dr. (Raven Road), Ottawa, ON K1A 0H3, Canada. Electronic address: 
      robert.letcher@ec.gc.ca.
LA  - eng
PT  - Journal Article
DEP - 20150603
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
OTO - NOTNLM
OT  - Dispersive solid phase extraction
OT  - Egg, fish and liver samples
OT  - Flame retardants
OT  - Organophosphate esters
OT  - Ultra-high performance liquid chromatography-tandem mass spectrometry
EDAT- 2015/08/02 06:00
MHDA- 2015/08/02 06:01
CRDT- 2015/08/02 06:00
PHST- 2015/03/24 00:00 [received]
PHST- 2015/05/15 00:00 [revised]
PHST- 2015/05/16 00:00 [accepted]
PHST- 2015/08/02 06:00 [entrez]
PHST- 2015/08/02 06:00 [pubmed]
PHST- 2015/08/02 06:01 [medline]
AID - S0003-2670(15)00745-X [pii]
AID - 10.1016/j.aca.2015.05.024 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2015 Jul 23;885:183-90. doi: 10.1016/j.aca.2015.05.024. Epub 2015 
      Jun 3.