PMID- 26232125
OWN - NLM
STAT- MEDLINE
DCOM- 20160825
LR  - 20181113
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 180
IP  - 5-6
DP  - 2015 Dec
TI  - Paracoccidioides brasiliensis Infection in Small Wild Mammals.
PG  - 435-40
LID - 10.1007/s11046-015-9928-8 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent in Brazil and other 
      Latin American countries. The etiological agents of PCM are the thermo-dimorphic 
      fungi Paracoccidioides brasiliensis and P. lutzii. Taking into account that the 
      natural habitat of Paracoccidioides spp. is still undefined, domestic and wild 
      animals could be useful as indicators of Paracoccidioides spp. presence in 
      endemic areas. The objective of this study was to evaluate the infection of small 
      wild mammals by P. brasiliensis in an endemic area for human PCM. Samples from 38 
      wild mammals from different species such as Akodon sp., Thaptomys nigrita, 
      Euryoryzomys russatus, Oligoryzomys nigripes, Monodelphis sp., Sooretamys 
      angouya, Abrawayaomys angouya, Abrawayaomys ruschii and Akodontinae sp. were 
      evaluated by ELISA, immunodiffusion, histopathology, nested PCR and culture. The 
      overall positivity to gp43 observed in the ELISA was 23.7%. Samples from heart 
      and liver of one O. nigripes were PCR positive, and the animal was also 
      seropositive to gp43 in ELISA. This study showed that wild animals living in 
      endemic areas for PCM are infected with P. brasiliensis and can be valuable 
      epidemiological markers of the fungus presence in the environment. This is the 
      first evidence of PCM infection in Akodon sp., E. russatus, T. nigrita and O. 
      nigripes.
FAU - Sbeghen, Monica Raquel
AU  - Sbeghen MR
AD  - Departamento de Ciencias Patologicas, Centro de Ciencias Biologicas, Universidade 
      Estadual de Londrina, Campus Universitario, Londrina, Parana, 86057-970, Brazil.
FAU - Zanata, Thais Bastos
AU  - Zanata TB
AD  - Departamento de Zoologia, Universidade Federal do Parana, Curitiba, Parana, 
      Brazil.
FAU - Macagnan, Rafaela
AU  - Macagnan R
AD  - Departamento de Ciencias Patologicas, Centro de Ciencias Biologicas, Universidade 
      Estadual de Londrina, Campus Universitario, Londrina, Parana, 86057-970, Brazil.
FAU - de Abreu, Kaue Cachuba
AU  - de Abreu KC
AD  - Departamento de Zoologia, Universidade Federal do Parana, Curitiba, Parana, 
      Brazil.
FAU - da Cunha, Willian Luiz
AU  - da Cunha WL
AD  - Reserva Particular do Patrimonio Natural Monte Sinai, Maua da Serra, Parana, 
      Brazil.
FAU - Watanabe, Maria Angelica Ehara
AU  - Watanabe MA
AD  - Departamento de Ciencias Patologicas, Centro de Ciencias Biologicas, Universidade 
      Estadual de Londrina, Campus Universitario, Londrina, Parana, 86057-970, Brazil.
FAU - de Camargo, Zoilo Pires
AU  - de Camargo ZP
AD  - Disciplina de Biologia Celular, Universidade Federal de Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Ono, Mario Augusto
AU  - Ono MA
AD  - Departamento de Ciencias Patologicas, Centro de Ciencias Biologicas, Universidade 
      Estadual de Londrina, Campus Universitario, Londrina, Parana, 86057-970, Brazil. 
      marioono@uel.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150801
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Antibodies, Fungal)
RN  - 0 (DNA, Fungal)
SB  - IM
MH  - Animals
MH  - Antibodies, Fungal/blood
MH  - Brazil
MH  - DNA, Fungal/analysis/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Heart/microbiology
MH  - Liver/microbiology
MH  - *Monodelphis
MH  - Paracoccidioides/*isolation & purification
MH  - Paracoccidioidomycosis/epidemiology/microbiology/*veterinary
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - *Sigmodontinae
OTO - NOTNLM
OT  - ELISA
OT  - Epidemiology
OT  - Paracoccidioidomycosis
OT  - Wild animals
EDAT- 2015/08/02 06:00
MHDA- 2016/08/26 06:00
CRDT- 2015/08/02 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/07/16 00:00 [accepted]
PHST- 2015/08/02 06:00 [entrez]
PHST- 2015/08/02 06:00 [pubmed]
PHST- 2016/08/26 06:00 [medline]
AID - 10.1007/s11046-015-9928-8 [pii]
AID - 10.1007/s11046-015-9928-8 [doi]
PST - ppublish
SO  - Mycopathologia. 2015 Dec;180(5-6):435-40. doi: 10.1007/s11046-015-9928-8. Epub 
      2015 Aug 1.