PMID- 26232324
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20210208
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 1
DP  - 2016 Jan
TI  - PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma.
PG  - 561-5
LID - 10.1007/s13277-015-3770-y [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck 
      malignancy worldwide. The molecular mechanism of LSCC remains not well 
      understood. PAQR3 (progestin and AdipoQ receptors) is a member of the progestin 
      and adipoQ receptor (PAQR) family. Many studies have showed that PAQR3 acts as a 
      new tumor suppressor. However, its expression and functions in LSCC are still 
      unknown. In our study, the expression of PAQR3 was downregulated in human LSCC 
      tissues compared to that in adjacent tissues. Moreover, overexpression of PAQR3 
      suppressed LSCC cell proliferation and invasion. In addition, PAQR3 inhibited 
      cell proliferation and invasion by regulating ERK phosphorylation. In conclusion, 
      our data demonstrated that PAQR3 acted a tumor suppressive role in LSCC, 
      providing a novel diagnostic and therapeutic option for LSCC in the future.
FAU - Wu, Qiang
AU  - Wu Q
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 
      150001, China.
FAU - Zhuang, Kun
AU  - Zhuang K
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 
      150001, China.
FAU - Li, Huijun
AU  - Li H
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 
      150001, China. lhuij1@126.com.
LA  - eng
PT  - Journal Article
DEP - 20150801
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (PAQR3 protein, human)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cell Proliferation
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Hep G2 Cells
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism
MH  - Membrane Proteins/*metabolism
MH  - Neoplasm Invasiveness
MH  - Phosphorylation
OTO - NOTNLM
OT  - ERK
OT  - Laryngeal squamous cell carcinoma
OT  - PAQR3
OT  - Tumor suppressor
EDAT- 2015/08/02 06:00
MHDA- 2017/02/09 06:00
CRDT- 2015/08/02 06:00
PHST- 2015/04/25 00:00 [received]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/08/02 06:00 [entrez]
PHST- 2015/08/02 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.1007/s13277-015-3770-y [pii]
AID - 10.1007/s13277-015-3770-y [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Jan;37(1):561-5. doi: 10.1007/s13277-015-3770-y. Epub 2015 Aug 
      1.