PMID- 26234573
OWN - NLM
STAT- MEDLINE
DCOM- 20160727
LR  - 20211203
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 54
IP  - 11
DP  - 2015 Nov
TI  - Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schonlein purpura 
      susceptibility in Iranian Azeri-Turkish patients.
PG  - 1269-74
LID - 10.1111/ijd.12940 [doi]
AB  - BACKGROUND: Henoch-Schonlein purpura (HSP) is the most common small-vessel 
      vasculitis and mainly affects children. Although its pathophysiology is unknown, 
      several studies have indicated the possible involvement of infections and genetic 
      factors in the development of HSP. The human leukocyte antigen (HLA) gene family 
      and several other genes involved in the inflammatory system have been studied. 
      The CCL2 gene, encoding chemokine monocyte chemo-attractant protein 1 
      (MCP-1/CCL2), is one of several cytokine genes clustered on chromosome 17. The 
      encoded protein displays chemotactic activity for monocytes. METHODS: This is a 
      case-control study comparing 36 children diagnosed with HSP within the Iranian 
      Azeri-Turkish ethnic population and 50 healthy adults from the same ethnic group. 
      CCL2, C-2518T polymorphism genotypes were determined by polymerase chain reaction 
      and by PVUII restriction enzyme analysis and subsequent agarose gel 
      electrophoresis. RESULTS: Our results showed a significant association between 
      the allelic and genotypic frequency of this gene and HSP disease in this cohort. 
      The results of this study indicate that frequencies of the T allele of CCL2 
      (P = 0.015) and the TT genotype (P = 0.004) are significantly higher in HSP 
      patients. A comparison of clinical symptoms and laboratory data with CCL2 C-2518T 
      polymorphism showed that patients with the TT genotype presented a higher 
      clinical score and more severe clinical features. CONCLUSIONS: MCP1/CCL2 C-2518T 
      gene polymorphism is associated with susceptibility to HSP. This is the first 
      study to report a significant association between MCP1/CCL2 C-2518T and a 
      susceptibility to HSP in this population.
CI  - (c) 2015 The International Society of Dermatology.
FAU - Bonyadi, Mortaza
AU  - Bonyadi M
AD  - Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of 
      Tabriz, Tabriz, Iran.
AD  - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Mohammadian, Tahereh
AU  - Mohammadian T
AD  - Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of 
      Tabriz, Tabriz, Iran.
FAU - Rafeey, Mandana
AU  - Rafeey M
AD  - Liver and Gastrointestinal Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Sadeghi Shabestri, Mahnaz
AU  - Sadeghi Shabestri M
AD  - Department of Clinical Immunology and Allergy, Tuberculosis and Lung Research 
      Center, Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Mortazavi, Fakhrossadat
AU  - Mortazavi F
AD  - Department of Clinical Immunology and Allergy, Tuberculosis and Lung Research 
      Center, Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Aliyari, Behzad
AU  - Aliyari B
AD  - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20150730
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Azerbaijan/ethnology
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - IgA Vasculitis/ethnology/*genetics
MH  - Infant
MH  - Iran/epidemiology
MH  - Male
MH  - Polymorphism, Genetic
MH  - Turkey/ethnology
EDAT- 2015/08/04 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/08/04 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/11/10 00:00 [revised]
PHST- 2014/12/03 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2015/08/04 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1111/ijd.12940 [doi]
PST - ppublish
SO  - Int J Dermatol. 2015 Nov;54(11):1269-74. doi: 10.1111/ijd.12940. Epub 2015 Jul 
      30.