PMID- 26234588
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20220309
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Print)
IS  - 1074-7427 (Linking)
VI  - 125
DP  - 2015 Nov
TI  - Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial 
      memory during senescence.
PG  - 36-46
LID - S1074-7427(15)00136-7 [pii]
LID - 10.1016/j.nlm.2015.07.015 [doi]
AB  - A decrease in N-methyl-D-aspartate receptor (NMDAR) function is associated with 
      age-related cognitive impairments. However, NMDAR antagonists are prescribed for 
      cognitive decline associated with age-related neurodegenerative disease, raising 
      questions as to the role of NMDAR activity in cognitive function during aging. 
      The current studies examined effects of NMDAR blockade on cognitive task that are 
      sensitive to aging. Young and middle-age rats were trained on the five-choice 
      serial reaction time task (5-CSRTT) and challenged with MK-801 (0.025, 0.05, and 
      0.1mg/kg or vehicle). Attention deficits were apparent in middle-age and 
      performance of young and middle-age rats was enhanced for low doses of MK-801 
      (0.025 and 0.05). The beneficial effects on attention were reversed by the 
      highest dose of MK-801. Older animals exhibited a delay-dependent impairment of 
      episodic spatial memory examined on a delayed-matching to place water maze task. 
      Similarly, a low dose of MK-801 (0.05mg/kg) impaired performance with increasing 
      delay and aged animals were more susceptible to disruption by NMDAR blockade. 
      Despite MK-801 impairment of episodic spatial memory, MK-801 had minimal effects 
      on spatial reference memory. Our results confirm that NMDARs contribute to 
      rapidly acquired and flexible spatial memory and support the idea that a decline 
      in NMDAR function contributes to the age-related impairments in cognition.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Guidi, Michael
AU  - Guidi M
AD  - Noldus Information Technology, 1503 Edwards Ferry Road, Suite 310, Leesburg, VA 
      20176, USA.
FAU - Rani, Asha
AU  - Rani A
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL 32610, USA.
FAU - Karic, Semir
AU  - Karic S
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL 32610, USA.
FAU - Severance, Barrett
AU  - Severance B
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL 32610, USA.
FAU - Kumar, Ashok
AU  - Kumar A
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL 32610, USA. Electronic address: Kash@ufl.edu.
FAU - Foster, Thomas C
AU  - Foster TC
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL 32610, USA. Electronic address: Foster1@ufl.edu.
LA  - eng
GR  - R01AG037984/AG/NIA NIH HHS/United States
GR  - R37 AG036800/AG/NIA NIH HHS/United States
GR  - R37AG036800/AG/NIA NIH HHS/United States
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - R01 AG037984/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150730
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Attention/*drug effects/physiology
MH  - Behavior, Animal/drug effects/physiology
MH  - Cognition/drug effects/physiology
MH  - Dizocilpine Maleate/*pharmacology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Male
MH  - *Memory, Episodic
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reaction Time/drug effects/physiology
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Spatial Memory/*drug effects/physiology
PMC - PMC4648716
MID - NIHMS712260
OTO - NOTNLM
OT  - Aging
OT  - Attention
OT  - Episodic memory
OT  - Hippocampus
OT  - MK-801
OT  - NMDA receptor
OT  - Prefrontal cortex
COIS- Authors do not have any competing financial interests.
EDAT- 2015/08/04 06:00
MHDA- 2016/09/10 06:00
PMCR- 2016/11/01
CRDT- 2015/08/04 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2015/06/22 00:00 [revised]
PHST- 2015/07/24 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2015/08/04 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - S1074-7427(15)00136-7 [pii]
AID - 10.1016/j.nlm.2015.07.015 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2015 Nov;125:36-46. doi: 10.1016/j.nlm.2015.07.015. Epub 
      2015 Jul 30.