PMID- 26235935
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20221207
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 106
IP  - 10
DP  - 2015 Oct
TI  - Human leukocyte antigen class II DRB1*1302 allele protects against cervical 
      cancer: At which step of multistage carcinogenesis?
PG  - 1448-54
LID - 10.1111/cas.12760 [doi]
AB  - We investigated the role of human leukocyte antigen (HLA) class II alleles in 
      multistage cervical carcinogenesis. Cross-sectional analysis for HLA association 
      with cervical cancer included 1253 Japanese women: normal cytology (NL, n = 341), 
      cervical intraepithelial neoplasia grade 1 (CIN1, n = 505), CIN grade 2 or 3 
      (CIN2/3, n = 96), or invasive cervical cancer (ICC, n = 311). The HLA class II 
      allele frequencies were compared by Fisher's exact test or the chi(2) -test. The 
      Bonferroni adjustment corrected for multiple comparisons. Among the study 
      subjects, 454 women with low-grade squamous intraepithelial lesion cytology were 
      prospectively monitored by cytology and colposcopy every 3-4 months to analyze 
      cumulative risk of CIN3 within the next 10 years in relation to HLA class II 
      alleles. HLA class II DRB1*1302 allele frequency was similar between women with 
      NL (11.7%) and CIN1 (11.9%), but significantly decreased to 5.2% for CIN2/3 and 
      5.8% for ICC (P = 0.0003). Correction for multiple testing did not change this 
      finding. In women with low-grade squamous intraepithelial lesion cytology, the 
      cumulative risk of CIN3 diagnosed within 10 years was significantly reduced among 
      DRB1*1302-positive women (3.2% vs. 23.7%, P = 0.03). In conclusion, the two 
      different types of analysis in this single study showed the protective effect of 
      the DRB1*1302 allele against progression from CIN1 to CIN2/3.
CI  - (c) 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on 
      behalf of Japanese Cancer Association.
FAU - Matsumoto, Koji
AU  - Matsumoto K
AD  - Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.
FAU - Maeda, Hiroo
AU  - Maeda H
AD  - Department of Transfusion Medicine and Cell Therapy, Saitama Medical Center, 
      Saitama Medical University, Saitama, Japan.
FAU - Oki, Akinori
AU  - Oki A
AD  - Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.
FAU - Takatsuka, Naoyoshi
AU  - Takatsuka N
AD  - Department of Health Economics, Gifu University Graduate School of Medicine, 
      Gifu, Japan.
FAU - Yasugi, Toshiharu
AU  - Yasugi T
AD  - Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.
FAU - Furuta, Reiko
AU  - Furuta R
AD  - Department of Pathology, Cancer Institute, Japanese Foundation of Cancer 
      Research, Tokyo, Japan.
FAU - Hirata, Ranko
AU  - Hirata R
AD  - Department of Transfusion Medicine and Cell Therapy, Saitama Medical Center, 
      Saitama Medical University, Saitama, Japan.
FAU - Mitsuhashi, Akira
AU  - Mitsuhashi A
AD  - Department of Reproductive Medicine, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Kawana, Kei
AU  - Kawana K
AD  - Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.
FAU - Fujii, Takuma
AU  - Fujii T
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Iwata, Takashi
AU  - Iwata T
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Hirai, Yasuo
AU  - Hirai Y
AD  - Departments of Gynecology and Cytopathology, Cancer Institute Hospital, Japanese 
      Foundation of Cancer Research, Tokyo, Japan.
FAU - Yokoyama, Masatoshi
AU  - Yokoyama M
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Yaegashi, Nobuo
AU  - Yaegashi N
AD  - Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 
      Sendai, Japan.
FAU - Watanabe, Yoh
AU  - Watanabe Y
AD  - Department of Obstetrics and Gynecology, Kinki University School of Medicine, 
      Osaka, Japan.
FAU - Nagai, Yutaka
AU  - Nagai Y
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of the 
      Ryukyus, Okinawa, Japan.
FAU - Yoshikawa, Hiroyuki
AU  - Yoshikawa H
AD  - Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.
CN  - Japan HPV and Cervical Cancer (JHACC) Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150925
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Carcinogenesis/*genetics
MH  - Cross-Sectional Studies
MH  - Disease Resistance/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Japan
MH  - Neoplasm Grading
MH  - Papillomaviridae/growth & development
MH  - Prospective Studies
MH  - Uterine Cervical Neoplasms/*genetics/pathology/virology
MH  - Young Adult
MH  - Uterine Cervical Dysplasia/*genetics/pathology/virology
PMC - PMC4638013
OTO - NOTNLM
OT  - cervical cancer
OT  - cervical intraepithelial neoplasia
OT  - human leukocyte antigen
OT  - human papillomavirus
OT  - low-grade squamous intraepithelial lesion
EDAT- 2015/08/04 06:00
MHDA- 2016/02/18 06:00
PMCR- 2015/10/01
CRDT- 2015/08/04 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/07/22 00:00 [revised]
PHST- 2015/07/29 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2015/08/04 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1111/cas.12760 [doi]
PST - ppublish
SO  - Cancer Sci. 2015 Oct;106(10):1448-54. doi: 10.1111/cas.12760. Epub 2015 Sep 25.