PMID- 26236404
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150803
LR  - 20181113
IS  - 1866-1947 (Print)
IS  - 1866-1955 (Electronic)
IS  - 1866-1947 (Linking)
VI  - 7
IP  - 1
DP  - 2015
TI  - Structural and functional connectivity in the default mode network in 22q11.2 
      deletion syndrome.
PG  - 23
LID - 10.1186/s11689-015-9120-y [doi]
LID - 23
AB  - BACKGROUND: The neural endophenotype associated with 22q11.2 deletion syndrome 
      (22q11DS) includes deviant cortical development and alterations in brain 
      connectivity. Resting-state functional magnetic resonance imaging (fMRI) findings 
      also reported disconnectivity within the default mode network (DMN). In this 
      study, we explored the relationship between functional and structural DMN 
      connectivity and their changes with age in patients with 22q11DS in comparison to 
      control participants. Given previous evidence of an association between DMN 
      disconnectivity and the manifestation of psychotic symptoms, we further 
      investigated this relationship in our group of patients with 22q11DS. METHODS: 
      T1-weighted, diffusion, and resting-state fMRI scans were acquired from 41 
      patients with 22q11DS and 43 control participants aged 6 to 28 years. A 
      data-driven approach based on independent component analysis (ICA) was used to 
      identify the DMN and to define regions of interest for the structural and 
      functional connectivity analysis. Prodromal psychotic symptoms were assessed in 
      adolescents and adults using the positive symptom scores of the Structured 
      Interview of Prodromal Syndromes (SIPS). Connectivity measures were compared 
      between groups and correlated with age. Repeating the between-group analysis in 
      three different age bins further assessed the presence of age-related alterations 
      in DMN connectivity. Structural and functional connectivity measures were then 
      correlated with the SIPS scores. RESULTS: A simultaneous reduction of functional 
      and structural connectivity between core medial nodes of the DMN was observed. 
      Furthermore, structural connectivity measures significantly increased with age in 
      the control group but not in patients with 22q11DS, suggesting the presence of an 
      age-related alteration of the DMN structural connections. No correlations were 
      found between the DMN disconnectivity and expression of prodromal symptoms in 
      22q11DS. CONCLUSIONS: These findings indicate the presence of functional and 
      structural DMN disconnectivity in 22q11DS and that patients with 22q11DS fail to 
      develop normal structural connections between medial DMN nodes. This suggests the 
      presence of altered neurodevelopmental trajectories in 22q11DS.
FAU - Padula, Maria Carmela
AU  - Padula MC
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland.
FAU - Schaer, Marie
AU  - Schaer M
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland ; Stanford Cognitive 
      and Systems Neuroscience Laboratory, Stanford University, Stanford, CA USA.
FAU - Scariati, Elisa
AU  - Scariati E
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland.
FAU - Schneider, Maude
AU  - Schneider M
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland.
FAU - Van De Ville, Dimitri
AU  - Van De Ville D
AD  - Department of Radiology and Medical Informatics, University of Geneva, Geneva, 
      Switzerland ; Medical Image Processing Lab, Institute of Bioengineering, Ecole 
      Polytechnique Federale de Lausanne, Lausanne, Switzerland.
FAU - Debbane, Martin
AU  - Debbane M
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland ; Adolescence 
      Clinical Psychology Research Unit, Faculty of Psychology and Educational 
      Sciences, Geneva, Switzerland ; Research Department of Clinical, Educational and 
      Health Psychology, University College London, London, U K.
FAU - Eliez, Stephan
AU  - Eliez S
AD  - Office Medico-Pedagogique, Department of Psychiatry, University of Geneva, Rue 
      David-Dufour 1, Case Postale 50, 1211 Geneve 8, Switzerland ; Department of 
      Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20150801
PL  - England
TA  - J Neurodev Disord
JT  - Journal of neurodevelopmental disorders
JID - 101483832
PMC - PMC4522079
OTO - NOTNLM
OT  - DTI
OT  - Maturation
OT  - Positive symptoms
OT  - Resting-state fMRI
OT  - Schizophrenia
OT  - Tractography
EDAT- 2015/08/04 06:00
MHDA- 2015/08/04 06:01
PMCR- 2015/08/01
CRDT- 2015/08/04 06:00
PHST- 2015/02/21 00:00 [received]
PHST- 2015/06/25 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2015/08/04 06:00 [pubmed]
PHST- 2015/08/04 06:01 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 9120 [pii]
AID - 10.1186/s11689-015-9120-y [doi]
PST - ppublish
SO  - J Neurodev Disord. 2015;7(1):23. doi: 10.1186/s11689-015-9120-y. Epub 2015 Aug 1.