PMID- 26237202
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20181202
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 23
IP  - 9
DP  - 2015 Sep
TI  - Circulating persistent organic pollutants and body fat distribution: Evidence 
      from NHANES 1999-2004.
PG  - 1903-10
LID - 10.1002/oby.21161 [doi]
AB  - OBJECTIVE: To evaluate and compare the correlations of various circulating 
      persistent organic pollutants (POPs) with fat mass percentages (FM%) of trunk, 
      leg, and whole body measured by dual-energy X-ray absorptiometry. METHODS: This 
      study included 2358 adults (>/=20 years) in the National Health and Nutrition 
      Examination Survey 1999-2004. Partial Pearson correlation coefficients were 
      calculated, after adjusting for major confounders, including age, smoking status, 
      and history of lactation and parity. Wolfe's method was used to compare 
      correlation coefficients derived from the same participants. RESULTS: Twelve POPs 
      showed significantly different correlations with fat depots in trunk and leg 
      regions. beta-hexachlorocyclohexane, heptachlorodibenzo-p-dioxin, 
      octachlorodibenzo-p-dioxin, and polychlorinated biphenyl (PCB)-126 showed 
      stronger positive correlations with trunk FM% than with leg FM%, whereas PCBs 
      with >/=6 chlorines were more inversely correlated with trunk FM% than leg FM%. 
      Age-stratified analysis showed stronger inverse correlations between POPs and 
      trunk FM% mainly in participants <40 years, whereas stronger positive 
      correlations between POPs and trunk FM% were observed in older participants. 
      CONCLUSIONS: Stronger associations between POPs and trunk fat as compared to leg 
      fat possibly indicated a more important role of trunk fat in the pharmacokinetics 
      of POPs, or a stronger effect of POPs, as endocrine disruptors, on trunk fat 
      metabolism.
CI  - (c) 2015 The Obesity Society.
FAU - Zong, Geng
AU  - Zong G
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, 
      Massachusetts, USA.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - Institute of Public Health, University of Southern Denmark, Odense, Denmark.
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, Massachusetts, USA.
FAU - Wu, Hongyu
AU  - Wu H
AD  - Icahn School of Medicine at Mount Sinai, Institute for Translational 
      Epidemiology, New York, New York, USA.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, 
      Massachusetts, USA.
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and 
      Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
LA  - eng
GR  - R00 HL098459/HL/NHLBI NIH HHS/United States
GR  - R00-HL098459/HL/NHLBI NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150803
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
CIN - Obesity (Silver Spring). 2015 Sep;23(9):1740. PMID: 26250618
MH  - Adult
MH  - Aged
MH  - Body Fat Distribution/*trends
MH  - Environmental Pollutants/*adverse effects
MH  - Female
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Organic Chemicals/*adverse effects
PMC - PMC4551580
MID - NIHMS690547
COIS- Disclosure: The authors declare no conflict of interest.
EDAT- 2015/08/04 06:00
MHDA- 2016/04/02 06:00
PMCR- 2016/05/18
CRDT- 2015/08/04 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/04/22 00:00 [revised]
PHST- 2015/05/01 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2015/08/04 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
PHST- 2016/05/18 00:00 [pmc-release]
AID - 10.1002/oby.21161 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2015 Sep;23(9):1903-10. doi: 10.1002/oby.21161. Epub 
      2015 Aug 3.