PMID- 26237262
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150804
LR  - 20220331
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 3
IP  - 1
DP  - 2014 Mar 17
TI  - Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving 
      Its Potential.
PG  - 280-309
LID - 10.3390/jcm3010280 [doi]
AB  - Preimplantation genetic diagnosis was developed nearly a quarter-century ago as 
      an alternative form of prenatal diagnosis that is carried out on embryos. 
      Initially offered for diagnosis in couples at-risk for single gene genetic 
      disorders, such as cystic fibrosis, spinal muscular atrophy and Huntington 
      disease, preimplantation genetic diagnosis (PGD) has most frequently been 
      employed in assisted reproduction for detection of chromosome aneuploidy from 
      advancing maternal age or structural chromosome rearrangements. Major 
      improvements have been seen in PGD analysis with movement away from older, less 
      effective technologies, such as fluorescence in situ hybridization (FISH), to 
      newer molecular tools, such as DNA microarrays and next generation sequencing. 
      Improved results have also started to be seen with decreasing use of Day 3 
      blastomere biopsy in favor of polar body or Day 5 trophectoderm biopsy. 
      Discussions regarding the scientific, ethical, legal and social issues 
      surrounding the use of sequence data from embryo biopsy have begun and must 
      continue to avoid concern regarding eugenic or inappropriate use of this 
      technology.
FAU - Stern, Harvey J
AU  - Stern HJ
AD  - Division of Reproductive Genetics, Genetics & IVF Institute, 3015 Williams Drive, 
      Fairfax, VA 22031, USA. hstern@givf.com.
AD  - Departments of Obstetrics and Gynecology, Pediatrics and Human Genetics, Virginia 
      Commonwealth University, Richmond, VA 23298, USA. hstern@givf.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140317
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC4449675
OTO - NOTNLM
OT  - chromosomal microarray
OT  - embryo biopsy
OT  - inherited genetic disorders
OT  - next generation sequencing
OT  - preimplantation genetic diagnosis
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/03/17
CRDT- 2015/08/04 06:00
PHST- 2014/01/22 00:00 [received]
PHST- 2014/02/12 00:00 [revised]
PHST- 2014/02/18 00:00 [accepted]
PHST- 2015/08/04 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/03/17 00:00 [pmc-release]
AID - jcm3010280 [pii]
AID - jcm-03-00280 [pii]
AID - 10.3390/jcm3010280 [doi]
PST - epublish
SO  - J Clin Med. 2014 Mar 17;3(1):280-309. doi: 10.3390/jcm3010280.