PMID- 26238885
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0028-3886 (Print)
IS  - 0028-3886 (Linking)
VI  - 63
IP  - 4
DP  - 2015 Jul-Aug
TI  - Chromosomal aberrations in atypical and anaplastic meningiomas: A fluorescence in 
      situ hybridization study.
PG  - 517-23
LID - 10.4103/0028-3886.161994 [doi]
AB  - OBJECTIVE: There is significant variability in the biologic behavior of 
      meningiomas, especially of atypical and anaplastic meningiomas, that cannot be 
      accounted for by just histology and grade of excision. The aim of our study was 
      to analyze deletions in regions 22q, 18p11, 1p32, and 14q32 in grade II and grade 
      III meningiomas and their correlation with tumor grade and recurrence. MATERIALS 
      AND METHODS: A total of 59 samples from 50 cases of grade II and grade III 
      meningiomas were analyzed with fluorescence in situ hybridization (FISH) 
      technique with locus specific probes. The types of aberrations and deletions were 
      analyzed and correlated with the tumor status. RESULTS: There was a statistically 
      significant increase in deletions in recurrences when compared to primary 
      surgeries. The mean mitotic index was higher in patients with deletions. Patients 
      with 18p deletions tended to be younger and had a significant association with 
      sheeting. 22q deletions were associated with hypercellular tumors. 1p, 14q, and 
      1p14q codeletion had a significant association with mitosis >/=7. CONCLUSION: This 
      is a first study from India analyzing all these four sites for deletions using 
      the FISH technique. Recurrent tumors and tumors with tendency to recur have a 
      higher frequency of deletions. The FISH study can be used to predict the behavior 
      of meningiomas if significant association is found. Further studies in larger 
      sets of patients along with their clinical correlation would help in categorizing 
      patients who have a higher risk of recurrence and help in guiding their clinical 
      management.
FAU - Sadashiva, Nishanth
AU  - Sadashiva N
FAU - Sugur, Harsh
AU  - Sugur H
FAU - Srinivas, Dwarakanath
AU  - Srinivas D
AD  - Department of Neurosurgery, National Institute of Mental Health and 
      Neurosciences, Bengaluru, Karnataka, India.
FAU - Santosh, Vani
AU  - Santosh V
FAU - Somanna, Sampath
AU  - Somanna S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neurol India
JT  - Neurology India
JID - 0042005
SB  - IM
EDAT- 2015/08/05 06:00
MHDA- 2015/08/05 06:01
CRDT- 2015/08/05 06:00
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2015/08/05 06:01 [medline]
AID - ni_2015_63_4_517_161994 [pii]
AID - 10.4103/0028-3886.161994 [doi]
PST - ppublish
SO  - Neurol India. 2015 Jul-Aug;63(4):517-23. doi: 10.4103/0028-3886.161994.