PMID- 26239388
OWN - NLM
STAT- MEDLINE
DCOM- 20170118
LR  - 20220331
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 23
IP  - 1
DP  - 2016 Jan
TI  - Cytokine Profiling in the Eutopic Endometrium of Adenomyosis During the 
      Implantation Window After Ovarian Stimulation.
PG  - 124-33
LID - 10.1177/1933719115597761 [doi]
AB  - In this study, we aimed to clarify the inflammatory cytokine profile of 
      endometrium in patients with adenomyosis during the implantation window after 
      ovarian stimulation. Eighteen patients with adenomyosis and 24 control patients 
      undergoing in vitro fertilization treatment were included in this prospective 
      case-control study. Regular gonadotropin-releasing hormone antagonist protocol 
      was used for ovarian stimulation. Endometrial samples were obtained 7 days after 
      human chorionic gonadotropin (hCG) injection (hCG + 7). Cytokine levels in 
      endometrium secretions from women with and without adenomyosis were assayed by 
      multiplex immunoassay, levels of interleukin (IL) 6 (25.9 +/- 6.6 vs 12.4 +/- 3.4 
      pg/mL; P = .001), IL-10 (10.4 +/- 2.9 vs 15.6 +/- 4.2 pg/mL; P = .001), IL-17 (11.9 +/- 
      3.0 vs 14.2 +/- 3.9 pg/mL; P = .046), interferon-gamma (11.7 +/- 3.5 vs 8.0 +/- 3.4 pg/mL; 
      P = .001), and monocyte chemoattractant protein-1 (MCP-1; 37.1 +/- 6.5 vs 16.4 +/- 
      3.2 pg/mL; P = .001) were significantly different between patients with 
      adenomyosis and control groups, respectively. Immunohistochemistry and 
      quantitative real-time polymerase chain reaction showed that CD-68+, IL-6, and 
      MCP-1 expression were higher and IL-10 was lower in adenomyosis endometrium 
      epithelia compared to controls. In conclusion, within the implantation window of 
      ovarian stimulation cycles, macrophages, IL-6, IL-10, and MCP-1 are expressed 
      differently in the endometrium of women with adenomyosis, which may correlate 
      with compromised endometrium receptivity. We postulated that cytokines of 
      endometrial secretions expressed differently in patients with adenomyosis may 
      contribute to impaired endometrium receptivity in these patients.
CI  - (c) The Author(s) 2015.
FAU - Zhihong, N
AU  - Zhihong N
AD  - Department of Obstetrics and Gynecology, IVF Unit, Ruijin Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Yun, F
AU  - Yun F
AD  - Department of Obstetrics and Gynecology, IVF Unit, Ruijin Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Pinggui, Z
AU  - Pinggui Z
AD  - Department of Obstetrics and Gynecology, IVF Unit, Ruijin Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Sulian, Z
AU  - Sulian Z
AD  - Department of Obstetrics and Gynecology, IVF Unit, Ruijin Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Zhang, Aijun
AU  - Zhang A
AD  - Department of Obstetrics and Gynecology, IVF Unit, Ruijin Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China ivfruijin@yeah.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150802
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adenomyosis/genetics/*metabolism
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cytokines/genetics/*metabolism
MH  - Embryo Implantation/*physiology
MH  - Endometrium/*metabolism
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - Interferon-gamma/genetics/metabolism
MH  - Interleukin-10/genetics/metabolism
MH  - Interleukin-6/genetics/metabolism
MH  - *Ovulation Induction
MH  - Prospective Studies
OTO - NOTNLM
OT  - adenomyosis
OT  - cytokines
OT  - endometrium
OT  - ovarian stimulation
EDAT- 2015/08/05 06:00
MHDA- 2017/01/19 06:00
CRDT- 2015/08/05 06:00
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2017/01/19 06:00 [medline]
AID - 1933719115597761 [pii]
AID - 10.1177/1933719115597761 [doi]
PST - ppublish
SO  - Reprod Sci. 2016 Jan;23(1):124-33. doi: 10.1177/1933719115597761. Epub 2015 Aug 
      2.