PMID- 26239557
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150804
LR  - 20231104
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 4
IP  - 6
DP  - 2015 Jun 9
TI  - Alternative Donor Transplantation for Acute Myeloid Leukemia.
PG  - 1240-68
LID - 10.3390/jcm4061240 [doi]
AB  - Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially 
      curative therapy for adult patients with acute myeloid leukemia (AML), but its 
      use for consolidation therapy after first remission with induction chemotherapy 
      used to be limited to younger patients and those with suitable donors. The median 
      age of AML diagnosis is in the late 60s. With the introduction of 
      reduced-intensity conditioning (RIC), many older adults are now eligible to 
      receive allo-HCT, including those who are medically less fit to receive 
      myeloablative conditioning. Furthermore, AML patients commonly have no human 
      leukocyte antigen (HLA)-identical or medically suitable sibling donor available 
      to proceed with allo-HCT. Technical advances in donor matching, suppression of 
      alloreactivity, and supportive care have made it possible to use alternative 
      donors, such as unrelated umbilical cord blood (UCB) and partially HLA-matched 
      related (haploidentical) donors. Outcomes after alternative donor allo-HCT are 
      now approaching the outcomes observed for conventional allo-HCT with matched 
      related and unrelated donors. Thus, with both UCB and haploidentical donors 
      available, lack of donor should rarely be a limiting factor in offering an 
      allo-HCT to adults with AML.
FAU - Bejanyan, Nelli
AU  - Bejanyan N
AD  - Division of Hematology, Oncology and Transplantation, University of Minnesota, 
      420 Delaware Street SE, Mayo Mail Code 480, Minneapolis, MN 55455, USA. 
      nbejanya@umn.edu.
FAU - Haddad, Housam
AU  - Haddad H
AD  - Hematology and Oncology Department, Staten Island University Hospital, 475 
      Seaview Ave, Staten Island, NY 10305, USA. husamhaddad@yahoo.com.
FAU - Brunstein, Claudio
AU  - Brunstein C
AD  - Division of Hematology, Oncology and Transplantation, University of Minnesota, 
      420 Delaware Street SE, Mayo Mail Code 480, Minneapolis, MN 55455, USA. 
      bruns072@umn.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150609
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC4484998
OTO - NOTNLM
OT  - AML
OT  - Haploidentical
OT  - Transplantation
OT  - UCB
OT  - alternative donor
EDAT- 2015/08/05 06:00
MHDA- 2015/08/05 06:01
PMCR- 2015/06/09
CRDT- 2015/08/05 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/05/18 00:00 [revised]
PHST- 2015/05/21 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2015/08/05 06:01 [medline]
PHST- 2015/06/09 00:00 [pmc-release]
AID - jcm4061240 [pii]
AID - jcm-04-01240 [pii]
AID - 10.3390/jcm4061240 [doi]
PST - epublish
SO  - J Clin Med. 2015 Jun 9;4(6):1240-68. doi: 10.3390/jcm4061240.