PMID- 26240488
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20181113
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 30
IP  - 8
DP  - 2015 Aug
TI  - Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes 
      Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.
PG  - 1101-9
LID - 10.3346/jkms.2015.30.8.1101 [doi]
AB  - Contribution of genetic predisposition to risk prediction of type 2 diabetes 
      mellitus (T2DM) was investigated using a prospective study in middle-aged adults 
      in Korea. From a community cohort of 6,257 subjects with 8 yr' follow-up, genetic 
      predisposition score with subsets of 3, 18, 36 selected single nucleotide 
      polymorphisms (SNPs) (genetic predisposition score; GPS-3, GPS-18, GPS-36) in 
      association with T2DM were determined, and their effect was evaluated using risk 
      prediction models. Rs5215, rs10811661, and rs2237892 were in significant 
      association with T2DM, and hazard ratios per risk allele score increase were 1.11 
      (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with 
      GPS-3, GPS-18, GPS-36, respectively. Changes in AUC upon addition of GPS were 
      significant in simple and clinical models, but the significance disappeared in 
      full clinical models with glycated hemoglobin (HbA1c). For net reclassification 
      index (NRI), significant improvement observed in simple (range 5.1%-8.6%) and 
      clinical (3.1%-4.4%) models were no longer significant in the full models. 
      Influence of genetic predisposition in prediction ability of T2DM incidence was 
      no longer significant when HbA1c was added in the models, confirming HbA1c as a 
      strong predictor for T2DM risk. Also, the significant SNPs verified in our 
      subjects warrant further research, e.g. gene-environmental interaction and 
      epigenetic studies.
FAU - Park, Hye Yin
AU  - Park HY
AD  - Center for Clinical Preventive Medicine, Seoul National University Bundang 
      Hospital, Seongnam, Korea. ; Department of Preventive Medicine, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Choi, Hyung Jin
AU  - Choi HJ
AD  - Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, 
      Korea.
FAU - Hong, Yun-Chul
AU  - Hong YC
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea. ; Institute of Environmental Medicine, Seoul National University 
      Medical Research Center, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150715
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*epidemiology/*genetics
MH  - Genetic Testing/methods
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - *Proportional Hazards Models
MH  - Reproducibility of Results
MH  - Republic of Korea/epidemiology
MH  - Risk Assessment/methods
MH  - Sensitivity and Specificity
PMC - PMC4520941
OTO - NOTNLM
OT  - Diabetes Mellitus
OT  - Genetic Predisposition
OT  - Hemoglobin A, Glycosylated
COIS- DISCLOSURE: The authors have no conflicts of interest to disclose.
EDAT- 2015/08/05 06:00
MHDA- 2016/04/26 06:00
PMCR- 2015/08/01
CRDT- 2015/08/05 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/04/09 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.3346/jkms.2015.30.8.1101 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2015 Aug;30(8):1101-9. doi: 10.3346/jkms.2015.30.8.1101. Epub 
      2015 Jul 15.