PMID- 26240570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150805
LR  - 20200929
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2015
DP  - 2015
TI  - Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell 
      Transplantation for Treatment of Intracerebral Hemorrhage.
PG  - 318269
LID - 10.1155/2015/318269 [doi]
LID - 318269
AB  - Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a 
      certain condition; however, the clinical application for treating nervous system 
      disease remains unclear. The aim is to assess the safety profile, feasibility, 
      and effectiveness of surgery combined with autologous BMSCs transplantation for 
      treating ICH. 206 ICH patients who had received surgical procedure were divided 
      into transplantation (n = 110) or control group (n = 96). For transplantation 
      group, BMSCs were injected into the perihemorrhage area in the base ganglia 
      through an intracranial drainage tube 5.5 (3.01-6.89) days after surgery, 
      followed by a second injection into the subarachnoid space through lumbar 
      puncture 4 weeks later. Neurologic impairment and daily activities were assessed 
      with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale 
      before transplantation and 6 months and 12 months after transplantation. Our 
      results revealed that, compared with control group, NIHSS score and Rankin scale 
      were both significantly decreased but Barthel index was increased in 
      transplantation group after 6 months. Interestingly, no significant difference 
      was observed between 12 months and 6 months. No transplantation-related adverse 
      effects were investigated during follow-up assessments. Our findings suggest that 
      surgery combined with autologous BMSCs transplantation is safe for treatment of 
      ICH, providing short-term therapeutic benefits.
FAU - Zhu, Jianxin
AU  - Zhu J
AD  - Department of Neurosurgery, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Xiao, Yilei
AU  - Xiao Y
AD  - Department of Neurosurgery, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Li, Zhongmin
AU  - Li Z
AD  - Department of Neurosurgery, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Han, Fabin
AU  - Han F
AD  - Neurological Laboratory, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Xiao, Taiwu
AU  - Xiao T
AD  - Department of Hematology, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Zhang, Zhiti
AU  - Zhang Z
AD  - Department of Neurosurgery, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
FAU - Geng, Fengyang
AU  - Geng F
AD  - Department of Neurosurgery, Liaocheng People's Hospital of Taishan Medical 
      University, Liaocheng 252000, China.
LA  - eng
PT  - Journal Article
DEP - 20150709
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4512614
EDAT- 2015/08/05 06:00
MHDA- 2015/08/05 06:01
PMCR- 2015/07/09
CRDT- 2015/08/05 06:00
PHST- 2014/10/08 00:00 [received]
PHST- 2014/12/30 00:00 [revised]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2015/08/05 06:01 [medline]
PHST- 2015/07/09 00:00 [pmc-release]
AID - 10.1155/2015/318269 [doi]
PST - ppublish
SO  - Stem Cells Int. 2015;2015:318269. doi: 10.1155/2015/318269. Epub 2015 Jul 9.