PMID- 26241170
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20181113
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 294
DP  - 2015 Nov 1
TI  - Yohimbine reinstates extinguished 3,4-methylenedioxymethamphetamine (MDMA; 
      ecstasy) seeking in rats with prior exposure to chronic yohimbine.
PG  - 1-6
LID - S0166-4328(15)30127-3 [pii]
LID - 10.1016/j.bbr.2015.07.056 [doi]
AB  - Although exposure to acute stress has been shown to reinstate extinguished 
      responding for a wide variety of drugs, no studies have investigated 
      stress-induced reinstatement in animals with a history of 
      3,4-methylenedioxymethamphetamine (MDMA; ecstasy) self-administration. Thus, rats 
      were trained to press a lever for MDMA (0.50 mg/kg/infusion) in daily sessions, 
      and lever pressing was subsequently extinguished in the absence of MDMA and 
      conditioned cues (light and tone). We then tested the ability of acute yohimbine 
      (2.0 mg/kg), a pharmacological stressor, to reinstate lever-pressing under 
      extinction conditions. Additionally, to model chronic stress, some rats were 
      injected daily with yohimbine (5.0 mg/kg x 10 days) prior to reinstatement tests. 
      To assess dopaminergic involvement, chronic yohimbine injections were combined 
      with injections of SCH-23390 (0.0 or 10.0 mug/kg), a dopamine D1-like receptor 
      antagonist. In a separate experiment, rats with a history of food 
      self-administration were treated and tested in the same way. Results showed that 
      acute yohimbine injections reinstated extinguished MDMA and food seeking, but 
      only in rats with a history of chronic yohimbine exposure. Co-administration of 
      SCH-23390 with chronic yohimbine injections prevented the potentiation of 
      subsequent food seeking, but not MDMA seeking. These results suggest that 
      abstinent MDMA users who also are exposed to chronic stress may be at increased 
      risk for future relapse, and also that the effects of chronic stress on relapse 
      may be mediated by different mechanisms depending on one's drug use history.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ball, Kevin T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA. Electronic address: kball@bloomu.edu.
FAU - Jarsocrak, Hanna
AU  - Jarsocrak H
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
FAU - Hyacinthe, Johanna
AU  - Hyacinthe J
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
FAU - Lambert, Justina
AU  - Lambert J
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
FAU - Lockowitz, James
AU  - Lockowitz J
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
FAU - Schrock, Jordan
AU  - Schrock J
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
LA  - eng
GR  - R15 DA035432/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150801
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Adrenergic alpha-2 Receptor Antagonists)
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Hallucinogens)
RN  - 0 (SCH 23390)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic alpha-2 Receptor Antagonists/*pharmacology
MH  - Animals
MH  - Behavior, Addictive/metabolism
MH  - Benzazepines/pharmacology
MH  - Conditioning, Operant/drug effects/physiology
MH  - Disease Models, Animal
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug-Seeking Behavior/*drug effects/physiology
MH  - Extinction, Psychological/drug effects/physiology
MH  - Feeding Behavior/drug effects/physiology
MH  - Food
MH  - Hallucinogens/*administration & dosage
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Stress, Psychological/physiopathology
MH  - Yohimbine/*pharmacology
PMC - PMC4564319
MID - NIHMS714092
OTO - NOTNLM
OT  - Dopamine
OT  - MDMA
OT  - Reinstatement
OT  - SCH-23390
OT  - Stress
OT  - Yohimbine
EDAT- 2015/08/05 06:00
MHDA- 2016/06/15 06:00
PMCR- 2016/11/01
CRDT- 2015/08/05 06:00
PHST- 2015/06/29 00:00 [received]
PHST- 2015/07/21 00:00 [revised]
PHST- 2015/07/27 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - S0166-4328(15)30127-3 [pii]
AID - 10.1016/j.bbr.2015.07.056 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Nov 1;294:1-6. doi: 10.1016/j.bbr.2015.07.056. Epub 2015 
      Aug 1.