PMID- 26241638
OWN - NLM
STAT- MEDLINE
DCOM- 20160714
LR  - 20150915
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 199
DP  - 2015 Nov 15
TI  - Role of Non-Transferrin-Bound Iron in the pathogenesis of cardiotoxicity in 
      patients with ST-elevation myocardial infarction assessed by Cardiac Magnetic 
      Resonance Imaging.
PG  - 326-32
LID - S0167-5273(15)30177-7 [pii]
LID - 10.1016/j.ijcard.2015.07.056 [doi]
AB  - BACKGROUND: Hereditary hemochromatosis, thalassemia and myelodysplastic syndromes 
      represent disease models with evidence of iron-related heart failure. 
      Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production 
      of reactive oxygen species and lipid peroxidation. In ST-elevation acute 
      myocardial infarction (STEMI) with evidence of microvascular obstruction (MVO) 
      and hemorrhage (HEM), HEM may be a source of iron-related cardiac toxicity 
      through NTBI and pro-inflammatory mediators. AIM OF THE STUDY: The study aims to 
      assess NTBI in patients with STEMI and its possible relationship with MVO and 
      HEM. METHODS AND RESULTS: NTBI, LPO-Malondialdehyde (MDA) and interleukin-6 
      (IL-6) were assessed in 15 patients with STEMI immediately before primary 
      percutaneous coronary intervention (PPCI) and at 3, 6, 9, 12, and 24h post-PPCI. 
      Cardiac Magnetic Resonance (CMR) was performed at 5days and 6months after STEMI. 
      Myocardial edema and HEM were assessed by T2 and T2* mapping. MVO and necrotic 
      area were assessed by early and late gadolinium enhancement (LGE). NTBI was 
      detected in 13/15 patients with the highest values in 4 patients with evidence of 
      MVO and HEM. NTBI levels were significantly related to CK-MB and troponin T 
      values. NTBI kinetics appeared to be different in patients with MVO and HEM (7/15 
      patients), with a peak value at 6h after PCI, in comparison with those with no 
      evidence of MVO and HEM, in whom NTBI values were lower and remained 
      indeterminable after the first 24h. CONCLUSIONS: The detection of elevated NTBI 
      values in patients with STEMI, MVO and HEM suggests a possible role of iron 
      cardiotoxicity in myocardial damage.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Roghi, Alberto
AU  - Roghi A
AD  - CMR Unit, Department of Cardiology and Cardiovascular Surgery, Niguarda Ca'Granda 
      Hospital, Milan, Italy. Electronic address: alberto.roghi@gmail.com.
FAU - Poggiali, Erika
AU  - Poggiali E
AD  - Department of Clinical Sciences and Community Health, University of Milan, Italy; 
      Department of Medicine and Medical Specialties, Ca'Granda Foundation IRCCS, 
      Ospedale Maggiore, Milan, Italy.
FAU - Duca, Lorena
AU  - Duca L
AD  - Department of Medicine and Medical Specialties, Ca'Granda Foundation IRCCS, 
      Ospedale Maggiore, Milan, Italy.
FAU - Mafrici, Antonio
AU  - Mafrici A
AD  - Cardiology Unit, San Carlo Borromeo Hospital, Milan, Italy.
FAU - Pedrotti, Patrizia
AU  - Pedrotti P
AD  - CMR Unit, Department of Cardiology and Cardiovascular Surgery, Niguarda Ca'Granda 
      Hospital, Milan, Italy.
FAU - Paccagnini, Stefania
AU  - Paccagnini S
AD  - Biochemistry Laboratories, Niguarda Ca'Granda Hospital, Milan, Italy.
FAU - Brenna, Sergio
AU  - Brenna S
AD  - Biochemistry Laboratories, Niguarda Ca'Granda Hospital, Milan, Italy.
FAU - Galli, Alessio
AU  - Galli A
AD  - Cardiovascular Disease Unit, Ca'Granda Foundation IRCCS, Ospedale Maggiore 
      Policlinico, Department of Medicine and Medical Specialties, Milan, Italy.
FAU - Consonni, Dario
AU  - Consonni D
AD  - Epidemiology Unit, Department of Preventive Medicine, Ca'Granda Foundation IRCCS, 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Cappellini, Maria Domenica
AU  - Cappellini MD
AD  - Department of Clinical Sciences and Community Health, University of Milan, Italy; 
      Department of Medicine and Medical Specialties, Ca'Granda Foundation IRCCS, 
      Ospedale Maggiore, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150723
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Transferrins)
RN  - 0 (Troponin T)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - E1UOL152H7 (Iron)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Creatine Kinase, MB Form/metabolism
MH  - Female
MH  - Hemorrhage/metabolism
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Iron/blood/*metabolism
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Microcirculation/physiology
MH  - Microvessels/pathology
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*metabolism/pathology/therapy
MH  - Myocarditis/metabolism/pathology
MH  - Myocardium/metabolism/pathology
MH  - Percutaneous Coronary Intervention
MH  - Prospective Studies
MH  - Reperfusion Injury/physiopathology
MH  - Transferrins/blood/*metabolism
MH  - Troponin T/blood/metabolism
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - Iron
OT  - Myocardial infarction
OT  - Non-Transferrin Bound Iron
OT  - Reperfusion injury
EDAT- 2015/08/05 06:00
MHDA- 2016/07/15 06:00
CRDT- 2015/08/05 06:00
PHST- 2015/03/12 00:00 [received]
PHST- 2015/07/18 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2016/07/15 06:00 [medline]
AID - S0167-5273(15)30177-7 [pii]
AID - 10.1016/j.ijcard.2015.07.056 [doi]
PST - ppublish
SO  - Int J Cardiol. 2015 Nov 15;199:326-32. doi: 10.1016/j.ijcard.2015.07.056. Epub 
      2015 Jul 23.