PMID- 26241705
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20181113
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 192
IP  - 10
DP  - 2015 Nov 15
TI  - Clinical and Immunological Factors in Emphysema Progression. Five-Year 
      Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary 
      Disease (LES-COPD).
PG  - 1171-8
LID - 10.1164/rccm.201504-0736OC [doi]
AB  - RATIONALE: Cross-sectional studies of T-cell responses to self-antigens correlate 
      with baseline emphysema severity. OBJECTIVES: We investigated whether clinical 
      and/or immunological factors could predict disease progression, such as 
      emphysema, FEV1, and 6-minute-walk distance (6MWD), in former and active smokers 
      in a 5-year prospective study. METHODS: We recruited 224 ever smokers over 40 
      years of age and with greater than a 15 pack-year smoking history. MEASUREMENTS 
      AND MAIN RESULTS: Repeated spirometry, 6MWD, and peripheral blood T-cell cytokine 
      responses to lung elastin fragments were measured. Baseline and repeat chest 
      computed tomography (CT) scans (34 to 65 mo apart) were used to quantify 
      emphysema progression. Of the 141 ever-smokers with baseline and repeat CT scans, 
      the mean (SD) annual rate of change in percent emphysema was +0.46 (0.92), 
      ranging from -1.8 to +4.1. In multivariable analyses, the rate of emphysema 
      progression was greater in subjects who had lower body mass index (BMI) (+0.15 
      per 5-unit decrease in BMI; 95% confidence interval, +0.03 to +0.29). In active 
      smokers, increased IFN-gamma and IL-6 T-cell responses had a positive association 
      with the annual rate of emphysema progression. Male sex and IL-6 T-cell responses 
      to elastin fragments were significantly associated with annual 6MWD decline, 
      whereas IL-13 was associated with an increase in annual 6MWD. CONCLUSIONS: The 
      rate of emphysema progression quantified by CT scans among ever-smokers was 
      highly variable; clinical factors and biomarkers explained only some of the 
      variability. Aggressive clinical care that targets active smokers with 
      autoreactive T cells and low BMI may temporize progression of emphysema.
FAU - Bhavani, Sivasubramanium
AU  - Bhavani S
AD  - 1 Department of Medicine.
FAU - Tsai, Chu-Lin
AU  - Tsai CL
AD  - 2 Department of Emergency Medicine, Massachusetts General Hospital, Harvard 
      Medical School, Boston, Massachusetts.
AD  - 3 Department of Emergency Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Perusich, Sarah
AU  - Perusich S
AD  - 1 Department of Medicine.
FAU - Hesselbacher, Sean
AU  - Hesselbacher S
AD  - 1 Department of Medicine.
FAU - Coxson, Harvey
AU  - Coxson H
AD  - 4 Department of Radiology, Vancouver General Hospital, University of British 
      Columbia, Vancouver, British Columbia, Canada; and.
FAU - Pandit, Lavannya
AU  - Pandit L
AD  - 1 Department of Medicine.
AD  - 5 Michael E. DeBakey Veterans Affairs Center for Translational Research on 
      Inflammatory Diseases, Houston Texas.
FAU - Corry, David B
AU  - Corry DB
AD  - 1 Department of Medicine.
AD  - 6 Department of Pathology and Immunology, and.
AD  - 7 Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas.
AD  - 5 Michael E. DeBakey Veterans Affairs Center for Translational Research on 
      Inflammatory Diseases, Houston Texas.
FAU - Kheradmand, Farrah
AU  - Kheradmand F
AUID- ORCID: 0000-0001-5343-103X
AD  - 1 Department of Medicine.
AD  - 6 Department of Pathology and Immunology, and.
AD  - 7 Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas.
AD  - 5 Michael E. DeBakey Veterans Affairs Center for Translational Research on 
      Inflammatory Diseases, Houston Texas.
LA  - eng
GR  - R01 HL082487/HL/NHLBI NIH HHS/United States
GR  - HL110883/HL/NHLBI NIH HHS/United States
GR  - R01 HL110883/HL/NHLBI NIH HHS/United States
GR  - I01 CX000104/CX/CSRD VA/United States
GR  - M01 RR000188/RR/NCRR NIH HHS/United States
GR  - HL082487/HL/NHLBI NIH HHS/United States
GR  - R01 HL117181/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000371/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Cytokines)
SB  - IM
CIN - Am J Respir Crit Care Med. 2015 Nov 15;192(10):1141-3. PMID: 26568233
MH  - Analysis of Variance
MH  - Cross-Sectional Studies
MH  - Cytokines/analysis/*immunology
MH  - Disease Progression
MH  - Emphysema/*etiology
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pulmonary Disease, Chronic Obstructive/complications/*immunology/physiopathology
MH  - Severity of Illness Index
MH  - Smoking/*adverse effects
MH  - T-Lymphocytes/*immunology
PMC - PMC4731622
OTO - NOTNLM
OT  - IFN-gamma
OT  - IL-17
OT  - IL-6
OT  - T cells
OT  - emphysema progression
EDAT- 2015/08/05 06:00
MHDA- 2016/02/24 06:00
PMCR- 2016/11/15
CRDT- 2015/08/05 06:00
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
PHST- 2016/11/15 00:00 [pmc-release]
AID - 10.1164/rccm.201504-0736OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2015 Nov 15;192(10):1171-8. doi: 
      10.1164/rccm.201504-0736OC.