PMID- 26241946
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20150908
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 33
IP  - 38
DP  - 2015 Sep 11
TI  - Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based 
      vector system.
PG  - 4827-36
LID - S0264-410X(15)01049-X [pii]
LID - 10.1016/j.vaccine.2015.07.072 [doi]
AB  - We developed a CTL vaccine vector by modification of the RPS-Vax system, a 
      mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an 
      oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic 
      transduction peptide (CTP) was integrated into the RPS-Vax system to generate 
      RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the 
      RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 
      was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 
      immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic 
      (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized 
      orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of 
      p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested 
      that the RPS-CTP vector system had potential for developing oral CTL vaccines 
      against infectious diseases.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Han, Seung-Soo
AU  - Han SS
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Lee, Jinjoo
AU  - Lee J
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Jung, Yideul
AU  - Jung Y
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Kang, Myeong-Ho
AU  - Kang MH
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Hong, Jung-Hyub
AU  - Hong JH
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Cha, Min-Suk
AU  - Cha MS
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Park, Yu-Jin
AU  - Park YJ
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Lee, Ezra
AU  - Lee E
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Yoon, Cheol-Hee
AU  - Yoon CH
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea.
FAU - Bae, Yong-Soo
AU  - Bae YS
AD  - Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, 
      Gyeonggi-Do, Republic of Korea. Electronic address: ysbae04@skku.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150801
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (AIDS Vaccines)
RN  - 0 (HIV Core Protein p24)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - AIDS Vaccines/administration & dosage/genetics/*immunology
MH  - Administration, Oral
MH  - Animals
MH  - *Genetic Vectors
MH  - HIV Core Protein p24/genetics/*immunology
MH  - HIV-1/genetics/*immunology
MH  - Mice, Inbred ICR
MH  - Mice, Transgenic
MH  - Poliovirus/*genetics
MH  - Survival Analysis
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Vaccines, Synthetic/administration & dosage/genetics/immunology
MH  - Vaccinia/prevention & control
OTO - NOTNLM
OT  - HIV-1 p24
OT  - Oral CTL vaccine
OT  - Poliovirus Sabin 1 vector
OT  - RPS-CTP CTL vector
OT  - Recombinant poliovirus
OT  - p24-specific CTL
EDAT- 2015/08/05 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/08/05 06:00
PHST- 2014/12/23 00:00 [received]
PHST- 2015/06/24 00:00 [revised]
PHST- 2015/07/23 00:00 [accepted]
PHST- 2015/08/05 06:00 [entrez]
PHST- 2015/08/05 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - S0264-410X(15)01049-X [pii]
AID - 10.1016/j.vaccine.2015.07.072 [doi]
PST - ppublish
SO  - Vaccine. 2015 Sep 11;33(38):4827-36. doi: 10.1016/j.vaccine.2015.07.072. Epub 
      2015 Aug 1.