PMID- 26242621 OWN - NLM STAT- MEDLINE DCOM- 20170713 LR - 20191210 IS - 1559-0100 (Electronic) IS - 1355-008X (Linking) VI - 52 IP - 3 DP - 2016 Jun TI - Role of (68)Ga-DOTATATE PET/CT in patients with multiple endocrine neoplasia type 1 (MEN1). PG - 488-94 LID - 10.1007/s12020-015-0702-y [doi] AB - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome predisposing to many endocrine and neuroendocrine tumors (NET). Conventional imaging (CI) cannot provide satisfactory results for all the different types of MEN1-related tumors. Objective of this prospective observational study was to evaluate the role of (68)Ga-DOTATATE PET/CT in MEN1 compared to CI. Diagnostic performance of (68)Ga-DOTATATE PET/CT for the detection of NET was evaluated as well as the prognostic role of SUVmax. Eighteen patients with genetically confirmed MEN1 were evaluated by (68)Ga-DOTATATE PET/CT, endoscopic ultrasounds, multidetector-row computed tomography, magnetic resonance imaging, and hormone/markers serum measurements. Four MEN1-related tumor sites (pancreas, pituitary, parathyroids, adrenals) were considered. Sensitivity and specificity of (68)Ga-DOTATATE PET/CT for the detection of NET were calculated. There was (68)Ga-DOTATATE PET/CT uptake in 11/11 patients with pancreatic lesions, in 9/12 with pituitary adenoma, in 5/15 with parathyroid enlargements, and in 5/7 with adrenal lesions. (68)Ga-DOTATATE PET/CT showed sensitivity and specificity of 100 and 100 % in pancreas, 75 and 83 % in pituitary, 28 and 100 % in parathyroids, and 62.5 and 100 % in adrenals, respectively. Compared with CI, no significant difference in sensitivity for pancreas, pituitary, and adrenals was found, while CI had a better sensitivity for parathyroids (p = 0.002). On the ROC analysis, progression of pancreatic lesions was significantly associated to SUVmax <12.3 (p < 0.05). (68)Ga-DOTATATE PET/CT is greatly helpful in the work-up of MEN1 providing a panoramic view of MEN1-related lesions. There is also a prognostic role of (68)Ga-PET in patients with MEN1-pancreatic lesions. FAU - Lastoria, Secondo AU - Lastoria S AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. s.lastoria@istitutotumori.na.it. FAU - Marciello, Francesca AU - Marciello F AD - Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Napoli, Via Sergio Pansini 5, 80131, Naples, Italy. francescamarciello81@gmail.com. FAU - Faggiano, Antongiulio AU - Faggiano A AD - Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Napoli, Via Sergio Pansini 5, 80131, Naples, Italy. FAU - Aloj, Luigi AU - Aloj L AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. FAU - Caraco, Corradina AU - Caraco C AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. FAU - Aurilio, Michela AU - Aurilio M AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. FAU - D'Ambrosio, Laura AU - D'Ambrosio L AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. FAU - Di Gennaro, Francesca AU - Di Gennaro F AD - Division of Nuclear Medicine, Department of Diagnostic Imaging and Radiotherapy, Istituto Nazionale Tumori "Fondazione G.Pascale" - IRCCS Napoli, Naples, Italy. FAU - Ramundo, Valeria AU - Ramundo V AD - Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Napoli, Via Sergio Pansini 5, 80131, Naples, Italy. FAU - Camera, Luigi AU - Camera L AD - Department of Biomorphological and Functional Sciences, "Federico II" University of Napoli, Naples, Italy. FAU - De Luca, Leonardo AU - De Luca L AD - Gastrointestinal Unit, "Pellegrini Hospital", Naples, Italy. FAU - Fonti, Rosa AU - Fonti R AD - Istitute of Biostructures and Bioimages (IBB), National Research Council, Naples, Italy. FAU - Napolitano, Vincenzo AU - Napolitano V AD - Department of General and Specialistic Surgery, Second University of Napoli, Caserta, Italy. FAU - Colao, Annamaria AU - Colao A AD - Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Napoli, Via Sergio Pansini 5, 80131, Naples, Italy. LA - eng PT - Journal Article PT - Observational Study DEP - 20150805 PL - United States TA - Endocrine JT - Endocrine JID - 9434444 RN - 0 (Organometallic Compounds) RN - 9L17Y0H71P (gallium Ga 68 dotatate) SB - IM MH - Adenoma/diagnostic imaging/pathology MH - Adolescent MH - Adult MH - Female MH - Humans MH - Hyperparathyroidism/diagnostic imaging/etiology/pathology MH - Male MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging MH - Neuroendocrine Tumors/*diagnostic imaging MH - *Organometallic Compounds MH - Parathyroid Neoplasms/diagnostic imaging/pathology MH - Pituitary Neoplasms/diagnostic imaging/pathology MH - Positron Emission Tomography Computed Tomography/*methods MH - Predictive Value of Tests MH - Sensitivity and Specificity MH - Young Adult OTO - NOTNLM OT - 68Ga-DOTATATE PET/CT OT - Hyperparathyroidism OT - MEN1 OT - Neuroendocrine tumor OT - Pituitary adenoma EDAT- 2015/08/06 06:00 MHDA- 2017/07/14 06:00 CRDT- 2015/08/06 06:00 PHST- 2015/04/27 00:00 [received] PHST- 2015/07/20 00:00 [accepted] PHST- 2015/08/06 06:00 [entrez] PHST- 2015/08/06 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] AID - 10.1007/s12020-015-0702-y [pii] AID - 10.1007/s12020-015-0702-y [doi] PST - ppublish SO - Endocrine. 2016 Jun;52(3):488-94. doi: 10.1007/s12020-015-0702-y. Epub 2015 Aug 5.