PMID- 26243179
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 23
IP  - 2
DP  - 2016 Apr
TI  - The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed 
      physiological myocardial (18)F-fluorodeoxyglucose (FDG) uptake and possible 
      minimal effects of unfractionated heparin use in patients with suspected cardiac 
      involvement sarcoidosis.
PG  - 244-52
LID - 10.1007/s12350-015-0226-0 [doi]
AB  - BACKGROUND: (18)F-fluorodeoxyglucose (FDG) PET plays an important role in the 
      detection of cardiac involvement sarcoidosis (CS). However, diffuse left 
      ventricle (LV) wall uptake sometimes makes it difficult to distinguish between 
      positive uptake and physiological uptake. The aims of this study were to evaluate 
      the effects of 18-h fasting with low-carbohydrate diet (LCD) vs a minimum of 6-h 
      fasting preparations on diffuse LV FDG uptake and free fatty acid (FFA) levels in 
      patients with suspected CS. METHODS: Eighty-two patients with suspected CS were 
      divided into 2 preparation protocols: one with a minimum 6-h fast without LCD 
      preparation (group A, n = 58) and the other with a minimum 18-h fast with LCD 
      preparation (group B, n = 24). All patients also received intravenous 
      unfractionated heparin (UFH; 50 IU/kg) before the injection of FDG. RESULTS: 
      Group A showed a higher percentage of diffuse LV uptake than did group B (27.6 vs 
      0.0%, P = .0041). Group B showed higher FFA levels (1159.1  +/-  393.0, 650.5  +/- 
       310.9 muEq/L, P < .0001) than did group A. Patients with diffuse LV uptake (n = 
      16) showed lower FFA levels than did other patients (n = 66) (432.1  +/-  296.1, 
      888.4  +/-  381.4 muEq/L, P < .0001). UFH administration significantly increased 
      FFAs in both groups, even in the patients with diffuse LV FDG uptake. 
      CONCLUSIONS: The 18-h fast with LCD preparation significantly reduced diffuse LV 
      uptake and increased FFA levels. In particular, the FFA level was significantly 
      lower in patients with LV diffuse uptake than in patients without LV diffuse 
      uptake. Acutely increasing plasma FFA through the use of UFH may not have a 
      significant role in reducing physiological LV FDG uptake.
FAU - Manabe, Osamu
AU  - Manabe O
AD  - Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Yoshinaga, Keiichiro
AU  - Yoshinaga K
AD  - Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan. kyoshi@nirs.go.jp.
AD  - Molecular Imaging Research Center, National Institute of Radiological Science, 
      4-9-1 Anage, Inage-Ku, Chiba, 263-8555, Japan. kyoshi@nirs.go.jp.
FAU - Ohira, Hiroshi
AU  - Ohira H
AD  - First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
FAU - Masuda, Atsuro
AU  - Masuda A
AD  - Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Sato, Takahiro
AU  - Sato T
AD  - First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
FAU - Tsujino, Ichizo
AU  - Tsujino I
AD  - First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
FAU - Yamada, Asuka
AU  - Yamada A
AD  - First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
FAU - Oyama-Manabe, Noriko
AU  - Oyama-Manabe N
AD  - Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, 
      Japan.
FAU - Hirata, Kenji
AU  - Hirata K
AD  - Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Nishimura, Masaharu
AU  - Nishimura M
AD  - First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
FAU - Tamaki, Nagara
AU  - Tamaki N
AD  - Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
LA  - eng
SI  - JPRN/UMIN000006533
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150805
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 9005-49-6 (Heparin)
SB  - IM
CIN - J Nucl Cardiol. 2016 Apr;23(2):253-5. PMID: 26268825
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging
MH  - *Diet, Carbohydrate-Restricted
MH  - Fasting
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Fluorodeoxyglucose F18/*pharmacokinetics
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Positron Emission Tomography Computed Tomography
MH  - Sarcoidosis/*diagnostic imaging
PMC - PMC4785205
OTO - NOTNLM
OT  - 18F-fluorodeoxyglucose
OT  - Cardiac sarcoidosis
OT  - free fatty acid
OT  - long fasting
OT  - positron emission tomography
EDAT- 2015/08/06 06:00
MHDA- 2016/12/15 06:00
PMCR- 2015/08/05
CRDT- 2015/08/06 06:00
PHST- 2014/11/26 00:00 [received]
PHST- 2015/06/13 00:00 [accepted]
PHST- 2015/08/06 06:00 [entrez]
PHST- 2015/08/06 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2015/08/05 00:00 [pmc-release]
AID - S1071-3581(23)06808-3 [pii]
AID - 226 [pii]
AID - 10.1007/s12350-015-0226-0 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2016 Apr;23(2):244-52. doi: 10.1007/s12350-015-0226-0. Epub 2015 
      Aug 5.