PMID- 26243755
OWN - NLM
STAT- MEDLINE
DCOM- 20170130
LR  - 20190816
IS  - 1552-5732 (Electronic)
IS  - 0890-3344 (Linking)
VI  - 32
IP  - 1
DP  - 2016 Feb
TI  - Role of Maternal Allergy on Immune Markers in Colostrum and Secretory 
      Immunoglobulin A in Stools of Breastfed Infants.
PG  - 160-7
LID - 10.1177/0890334415598783 [doi]
AB  - BACKGROUND: Although protection against infectious diseases has been observed 
      among breastfed infants as compared to formula-fed infants, possible benefits of 
      breastfeeding by allergic mothers for allergy prevention remain controversial. 
      OBJECTIVES: The aims of this study were to determine whether maternal allergy 
      would influence immune markers (secretory immunoglobulin A [sIgA], interleukin-8 
      [IL-8], soluble CD14 [sCD14]) in colostrum and the associations between maternal 
      allergy and fecal sIgA levels in breastfed infants. METHODS: Study subjects were 
      enrolled from the Prediction of Allergies in Taiwanese Children (PATCH) birth 
      cohort study. Colostrum samples were obtained from 98 lactating mothers. Stool 
      samples were collected from 108 infants within 5 days after birth and at 2 and 4 
      months of age. We compared concentrations of sIgA, IL-8, and sCD14 in colostrum 
      between mothers with and without a history of allergic disease and allergic 
      sensitization. We also compared fecal sIgA levels between breastfed and 
      formula-fed infants and between infants with allergic and nonallergic mothers. 
      RESULTS: The sIgA concentrations were significantly higher in colostrum from 
      allergic mothers than from nonallergic mothers (P = .01) and from allergic 
      mothers who were immunoglobulin E (IgE) sensitized compared to nonallergic 
      mothers who were not IgE sensitized (P = .023). Breastfed infants had 
      significantly higher fecal sIgA levels as compared to formula-fed infants, 
      regardless of whether their lactating mothers had an allergy (P < .05). 
      CONCLUSION: We found that breastfeeding is associated with increased infants' 
      fecal sIgA levels and may have potential protective effects to the infants during 
      the first 4 months of life, regardless of whether their lactating mothers have 
      allergies.
CI  - (c) The Author(s) 2015.
FAU - Hua, Man-Chin
AU  - Hua MC
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan Chang 
      Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Chen, Chien-Chang
AU  - Chen CC
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan Division of 
      Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Yao, Tsung-Chieh
AU  - Yao TC
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan Division of Allergy, 
      Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Tsai, Ming-Han
AU  - Tsai MH
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan Chang 
      Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Liao, Sui-Ling
AU  - Liao SL
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan Chang 
      Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Lai, Shen-Hao
AU  - Lai SH
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan Division of Chest, 
      Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan Chang 
      Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan Division of Allergy, 
      Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan Division of Allergy, 
      Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan long@adm.cgmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150804
PL  - United States
TA  - J Hum Lact
JT  - Journal of human lactation : official journal of International Lactation 
      Consultant Association
JID - 8709498
RN  - 0 (Biomarkers)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Immunoglobulin A, Secretory)
RN  - 0 (Interleukin-8)
RN  - 0 (Lipopolysaccharide Receptors)
MH  - Adult
MH  - Biomarkers/metabolism
MH  - *Breast Feeding
MH  - Case-Control Studies
MH  - Colostrum/*immunology
MH  - Feces/chemistry
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*immunology/prevention & control
MH  - Immunoglobulin A, Secretory/*metabolism
MH  - Infant
MH  - Infant Formula
MH  - Infant, Newborn
MH  - Interleukin-8/*metabolism
MH  - Lipopolysaccharide Receptors/*metabolism
MH  - Male
MH  - Prospective Studies
MH  - Protective Factors
OTO - NOTNLM
OT  - allergy
OT  - breastfeeding
OT  - colostrum
OT  - infants
OT  - interleukin-8
OT  - secretory immunoglobulin A
OT  - soluble CD14
OT  - stool
EDAT- 2015/08/06 06:00
MHDA- 2017/01/31 06:00
CRDT- 2015/08/06 06:00
PHST- 2014/09/09 00:00 [received]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/08/06 06:00 [entrez]
PHST- 2015/08/06 06:00 [pubmed]
PHST- 2017/01/31 06:00 [medline]
AID - 0890334415598783 [pii]
AID - 10.1177/0890334415598783 [doi]
PST - ppublish
SO  - J Hum Lact. 2016 Feb;32(1):160-7. doi: 10.1177/0890334415598783. Epub 2015 Aug 4.