PMID- 26244490
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20151007
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 100
IP  - 10
DP  - 2015 Oct
TI  - The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for 
      Clinicians.
PG  - 3613-21
LID - 10.1210/jc.2015-2338 [doi]
AB  - CONTEXT: There is growing interest in the relationship between bone marrow fat 
      (BMF), bone mineral density (BMD), and fractures. Moreover, BMF might be 
      influenced by metabolic diseases associated with bone loss and fractures, such as 
      type 2 diabetes mellitus (T2DM), anorexia nervosa (AN), and obesity. METHODS: The 
      primary-source literature for this review was acquired using a PubMed search for 
      articles published between January 2000 and April 2015. Search terms included 
      BMF, BMD, fractures, T2DM, AN, and obesity. The titles and abstracts of all 
      articles were reviewed for relevant subjects. RESULTS: Magnetic resonance 
      imaging, with or without spectroscopy, was used to noninvasively quantify BMF in 
      humans. A negative relationship was found between BMD and BMF in both healthy and 
      osteopenic/osteoporotic populations. Data are lacking on the relationship between 
      BMF and fractures. Studies in populations of individuals with metabolic diseases 
      such as T2DM, AN, and obesity have shown BMF abnormalities. CONCLUSIONS: We 
      conclude that most human data demonstrate an inverse relationship between BMF and 
      BMD, but data on the relationship with fractures are inconsistent and need 
      further study. In daily practice, the usefulness for clinicians of assessing BMF 
      using magnetic resonance imaging is still limited. However, the perspectives are 
      exciting, particularly in terms of improving the diagnosis and management of 
      osteoporosis.
FAU - Paccou, Julien
AU  - Paccou J
AD  - Universite de Lille (J.P., A.C., G.P., B.C.), Faculte de Chirurgie Dentaire, 
      Place de Verdun, 59000 Lille, France; Service de Rhumatologie (J.P., B.C.), 
      Centre Hospitalier Regional Universitaire, 59000 Lille, France; Universite du 
      Littoral Cote (P.H.), 62327 Boulogne-sur-Mer, France; and Service d'Imagerie 
      Musculo-Squelettique (A.C.), Centre Hospitalier Regional Universitaire, 59000 
      Lille, France.
FAU - Hardouin, Pierre
AU  - Hardouin P
AD  - Universite de Lille (J.P., A.C., G.P., B.C.), Faculte de Chirurgie Dentaire, 
      Place de Verdun, 59000 Lille, France; Service de Rhumatologie (J.P., B.C.), 
      Centre Hospitalier Regional Universitaire, 59000 Lille, France; Universite du 
      Littoral Cote (P.H.), 62327 Boulogne-sur-Mer, France; and Service d'Imagerie 
      Musculo-Squelettique (A.C.), Centre Hospitalier Regional Universitaire, 59000 
      Lille, France.
FAU - Cotten, Anne
AU  - Cotten A
AD  - Universite de Lille (J.P., A.C., G.P., B.C.), Faculte de Chirurgie Dentaire, 
      Place de Verdun, 59000 Lille, France; Service de Rhumatologie (J.P., B.C.), 
      Centre Hospitalier Regional Universitaire, 59000 Lille, France; Universite du 
      Littoral Cote (P.H.), 62327 Boulogne-sur-Mer, France; and Service d'Imagerie 
      Musculo-Squelettique (A.C.), Centre Hospitalier Regional Universitaire, 59000 
      Lille, France.
FAU - Penel, Guillaume
AU  - Penel G
AD  - Universite de Lille (J.P., A.C., G.P., B.C.), Faculte de Chirurgie Dentaire, 
      Place de Verdun, 59000 Lille, France; Service de Rhumatologie (J.P., B.C.), 
      Centre Hospitalier Regional Universitaire, 59000 Lille, France; Universite du 
      Littoral Cote (P.H.), 62327 Boulogne-sur-Mer, France; and Service d'Imagerie 
      Musculo-Squelettique (A.C.), Centre Hospitalier Regional Universitaire, 59000 
      Lille, France.
FAU - Cortet, Bernard
AU  - Cortet B
AD  - Universite de Lille (J.P., A.C., G.P., B.C.), Faculte de Chirurgie Dentaire, 
      Place de Verdun, 59000 Lille, France; Service de Rhumatologie (J.P., B.C.), 
      Centre Hospitalier Regional Universitaire, 59000 Lille, France; Universite du 
      Littoral Cote (P.H.), 62327 Boulogne-sur-Mer, France; and Service d'Imagerie 
      Musculo-Squelettique (A.C.), Centre Hospitalier Regional Universitaire, 59000 
      Lille, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150805
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Adipose Tissue/metabolism/*pathology
MH  - *Bone Density
MH  - Bone Marrow/metabolism/*pathology
MH  - Fractures, Bone/*metabolism/pathology
MH  - Humans
MH  - Osteoporosis/metabolism/*pathology
EDAT- 2015/08/06 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/08/06 06:00
PHST- 2015/08/06 06:00 [entrez]
PHST- 2015/08/06 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - 10.1210/jc.2015-2338 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2015 Oct;100(10):3613-21. doi: 10.1210/jc.2015-2338. 
      Epub 2015 Aug 5.