PMID- 26245120
OWN - NLM
STAT- MEDLINE
DCOM- 20151114
LR  - 20181202
IS  - 1000-7423 (Print)
IS  - 1000-7423 (Linking)
VI  - 33
IP  - 2
DP  - 2015 Apr
TI  - [The Levels of IL-4, IL-9, and IgE in Patients Infected with Intestinal Helminths 
      and their Clinical Values].
PG  - 110-3
AB  - OBJECTIVE: To investigate the serum levels of interleukin-4 (IL-4), interleukin-9 
      (IL-9), and immunoglobulin E (IgE) in the patients infected with intestinal 
      helminths, and study their relationship to the clinical symptoms or species of 
      the helminths. METHODS: This study was carried out in the Department of 
      Paediatrics, Henan Provincial People's Hospital from January 2010 to July 2014. 
      The blood samples were collected from 55 infected patients. Among the 55 cases, 
      18 cases (32.7%) were with ascaris infection, 8 cases (14.5%) of hookworm 
      infection, 7 cases (12.7%) of whipworm infection, and 22 cases (40%) of pinworm 
      infection. ELISA were used to measure the levels of IL-4, IL-9, and IgE in 
      peripheral blood samples from the patients and 15 healthy volunteers. The 
      relationship between the concentration of the cytokines and clinical symptoms or 
      species of the parasites was analyzed. RESULTS: The serum levels of IL-4, IL-9, 
      and IgE in infection group were (157.42 +/- 41) pg/ml, (59.9 +/- 21.7) pg/ml, and 
      (316.6 +/- 129) IU/ml, respectively, which were higher than that of the healthy 
      control[ IL-4 (39.01 +/- .5) pg/ml, IL-9 (21.3 +/- 12.5) pg/m, IgE (127.7 +/- 57.6) 
      IU/ml] (P > 0.01). After treatment by albendazole in the infection group, the 
      level of IL-4, IL-9, and IgE decreased to (98.1 +/- 41.7) pg/ml, (38.7 +/- 14.1) 
      pg/ml, and (253.1 +/- 94.0) IU/ml, respectively, but still higher than that of the 
      control (P < 0.05). IL-9 level in patients with upper gastrointestinal hemorrhage 
      was (76.1 +/- 23.5) pg/ml, which was higher than that of those with abdominal 
      discomfort or disruption to bowel habits [(54.3 +/- 22.1) g/ml] (P < 0.05), but 
      lower than that of those with allergic dermatitis [(108.5 +/- 33.4) pg/ml] (P < 
      0.05). No significant difference was found in the levels of IL-4 and IgE among 
      the above three groups. The level of IL-9 in patients infected with pinworms was 
      (120.3 +/- 41.0) pg/ml, which was higher than that of ascaris infection group 
      [(90.1 +/- 29.7) pg/ml], hookworm infection group [(77.3 +/- 18.3) pg/ml], and 
      whipworm infection group [(62.5 +/- 24.3) pg/ml] (P < 0.01). There was no 
      significant difference in the serum level of IL-9 between ascaris infection group 
      and hookworm infection group (P > 0.05), whereas the IL-9 level in ascaris 
      infection group and hookworm infection group was higher than that of whipworm 
      infection group [(62.5 +/- 24.3) pg/ ml] (P < 0.01). There were no significant 
      difference in the serum level of IL-4 and IgE among the patients infected with 
      the species of different helminthes (P > 0.05). CONCLUSION: The levels of IL-4, 
      IgE, and IL-9 are considerably related with intestinal helminth infection, while 
      IL-9 level varied with different helminth species and clinical symptoms.
FAU - Guo, Ai-ye
AU  - Guo AY
FAU - Lin, Xi-meng
AU  - Lin XM
FAU - Zhang, Yu-qin
AU  - Zhang YQ
FAU - Wu, Hui
AU  - Wu H
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
JT  - Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of 
      parasitology & parasitic diseases
JID - 8709992
RN  - 0 (IL4 protein, human)
RN  - 0 (IL9 protein, human)
RN  - 0 (Interleukin-9)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Intestinal helminthiasis
SB  - IM
MH  - Ancylostomiasis
MH  - Animals
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Helminthiasis
MH  - Humans
MH  - Immunoglobulin E
MH  - Interleukin-4
MH  - Interleukin-9
MH  - *Intestinal Diseases, Parasitic
MH  - Trichuriasis
EDAT- 2015/08/08 06:00
MHDA- 2015/11/15 06:00
CRDT- 2015/08/07 06:00
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2015/11/15 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2015 Apr;33(2):110-3.