PMID- 26245274
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20181202
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 20
IP  - 4
DP  - 2016 May
TI  - Relationship between periodontal parameters and plasma cytokine profiles in 
      pregnant woman with preterm birth or low birth weight.
PG  - 669-74
LID - 10.1007/s00784-015-1553-x [doi]
AB  - OBJECTIVES: The aim was to determine whether clinical periodontal parameters are 
      associated with plasma anti- and/or pro-inflammatory cytokines in pregnant woman 
      with preterm birth (PB) or low birth weight (LBW) neonates. MATERIALS AND 
      METHODS: An observational case-control study was performed in 131 puerperal 
      women: mothers of PB/LBW neonates (cases, n = 67) and mothers of full-term 
      normal-weight neonates (controls, n = 64). Sociodemographic and periodontal data 
      was gathered from all participants, and interleukin (IL)-1beta, IL-6, IL-8, IL-10, 
      IL-17, IL-23, and tumor necrosis factor alpha (TNF-alpha) were determined in plasma. 
      RESULTS: In multiple linear regression models, clinical attachment loss was 
      associated with TNF-alpha (0.28 +/- 0.14; 95% confidence interval (CI) [0.006, 0.553]) 
      and IL-1beta (0.43 +/- 0.21; 95%CI [0.018, 0.842]), independent of group membership. 
      IL-1beta (-1.67 +/- 0.27, 95%CI [-2.199, -1.141]), IL-6 (-0.86 +/- 0.27; 95%CI [-1.389, 
      -0.331]), and IL-8 (-3.84 +/- 0.50, 95%CI [-4.820, -2.860]) were lower, and IL-10 
      (0.86 +/- 0.26; 95%CI [0.350, 1.370]) was higher in cases versus controls after 
      adjusting for potential confounders. CONCLUSIONS: Clinical attachment loss was 
      associated with plasma TNF-alpha and IL-1beta levels. No plasma cytokine profiles 
      suggestive of systemic inflammatory response were observed in the pregnant women 
      with PB/LBW neonates. CLINICAL RELEVANCE: Clinical attachment loss, as the main 
      periodontal measure, is associated with TNF-alpha and IL-1beta plasma levels in pregnant 
      women. No relationship was found between PB/LBW and the markers of systemic 
      inflammatory response assessed in this study.
FAU - Mesa, Francisco
AU  - Mesa F
AD  - Periodontology Department, School of Dentistry, University of Granada, Campus de 
      Cartuja s/n, 18071, Granada, Spain. fmesa@ugr.es.
FAU - Pozo, Elena
AU  - Pozo E
AD  - Periodontology Department, School of Dentistry, University of Granada, Campus de 
      Cartuja s/n, 18071, Granada, Spain.
FAU - O'Valle, Francisco
AU  - O'Valle F
AD  - Pathology Department, School of Medicine, University of Granada, Avda. De Madrid 
      s/n, 18012, Granada, Spain.
FAU - Puertas, Alberto
AU  - Puertas A
AD  - Department of Obstetrics and Gynecology, Virgen de las Nieves University 
      Hospital, Avda. Fuerzas Armadas 2, 18014, Granada, Spain.
FAU - Magan-Fernandez, Antonio
AU  - Magan-Fernandez A
AD  - Periodontology Department, School of Dentistry, University of Granada, Campus de 
      Cartuja s/n, 18071, Granada, Spain.
FAU - Rosel, Eva
AU  - Rosel E
AD  - Department of Preventive Dentistry and Epidemiology, School of Dentistry, 
      University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
FAU - Bravo, Manuel
AU  - Bravo M
AD  - Department of Preventive Dentistry and Epidemiology, School of Dentistry, 
      University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
LA  - eng
PT  - Journal Article
DEP - 20150807
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
EIN - Clin Oral Investig. 2020 Oct;24(10):3721-3722. PMID: 32880689
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - *Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Inflammation
MH  - Interleukin-10
MH  - *Periodontal Index
MH  - Pregnancy
MH  - *Premature Birth
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Chronic periodontitis
OT  - Cytokines
OT  - Enzyme-linked immunosorbent assay
OT  - Premature birth
EDAT- 2015/08/08 06:00
MHDA- 2018/06/23 06:00
CRDT- 2015/08/07 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
AID - 10.1007/s00784-015-1553-x [pii]
AID - 10.1007/s00784-015-1553-x [doi]
PST - ppublish
SO  - Clin Oral Investig. 2016 May;20(4):669-74. doi: 10.1007/s00784-015-1553-x. Epub 
      2015 Aug 7.