PMID- 26245912
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171102
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 17
IP  - 6
DP  - 2016 Jun
TI  - Differences in apical and non-apical types of hypertrophic cardiomyopathy: a 
      prospective analysis of clinical, echocardiographic, and cardiac magnetic 
      resonance findings and outcome from 350 patients.
PG  - 678-86
LID - 10.1093/ehjci/jev192 [doi]
AB  - AIMS: Apical hypertrophic cardiomyopathy (ApHCM) is thought to have a favourable 
      clinical outcome, compared with other types of HCM. We sought to investigate the 
      clinical and anatomical differences in cardiovascular imaging between ApHCM and 
      non-ApHCM. METHODS AND RESULTS: A total of 350 patients diagnosed with HCM 
      underwent cardiovascular magnetic resonance (CMR) and echocardiography. All 
      enrolled subjects were prospectively followed up for adverse clinical outcomes. 
      Eighty-five patients were classified as ApHCM. On CMR, the amount and proportion 
      of late gadolinium enhancement (LGE) as well as left ventricular volumetric 
      parameters were evaluated. Echocardiographic evaluations included diastolic 
      function and global strain. Patients with ApHCM were less likely to present with 
      history of syncope and have less frequency of family history of sudden cardiac 
      death than those with non-ApHCM. Functional class was also more favourable in 
      ApHCM [frequency of New York Heart Association (NYHA) class I; 89.4 vs. 66.8%, P 
      < 0.001]. LGE was less frequently detected (87.1 vs. 93.9%, P = 0.04), and the 
      amount of LGE was significantly smaller in ApHCM (7.0 +/- 6.0 vs. 14.6 +/- 10.5%, P < 
      0.001). The E/e' level and left atrial volume index were also lower in ApHCM 
      patients (all P < 0.001). During follow-up, a composite of adverse clinical 
      events including cardiac death, admission for heart failure, and cerebrovascular 
      accident was higher in patients with ApHCM than those with non-ApHCM (P = 0.01). 
      CONCLUSION: ApHCM showed a relatively small burden of myocardial fibrosis and 
      less severe diastolic dysfunction and subsequently more favourable clinical 
      manifestations in comparison with other HCMs. This may be one explanation of why 
      most patients with ApHCM show a benign course of disease compared with non-ApHCM.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2015. For permissions please email: journals.permissions@oup.com.
FAU - Kim, Eun Kyoung
AU  - Kim EK
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Lee, Sang-Chol
AU  - Lee SC
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea sc.lea@samsung.com.
FAU - Hwang, Ji Won
AU  - Hwang JW
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Chang, Sung-A
AU  - Chang SA
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Park, Sung-Ji
AU  - Park SJ
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - On, Young Keun
AU  - On YK
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Park, Kyoung Min
AU  - Park KM
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Choe, Yeon Hyeon
AU  - Choe YH
AD  - Department of Radiology, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, Sung-Mok
AU  - Kim SM
AD  - Department of Radiology, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Park, Seung Woo
AU  - Park SW
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
FAU - Oh, Jae K
AU  - Oh JK
AD  - Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, 
      Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 81 
      Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Division of Cardiovascular Diseases, 
      Mayo Clinic College of Medicine, Rochester, MN, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20150804
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/mortality/*pathology
MH  - Death, Sudden, Cardiac
MH  - Echocardiography/*methods
MH  - Female
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Survival Analysis
OTO - NOTNLM
OT  - Apical hypertrophy
OT  - Cardiac magnetic resonance imaging
OT  - Hypertrophic cardiomyopathy
EDAT- 2015/08/08 06:00
MHDA- 2017/11/03 06:00
CRDT- 2015/08/07 06:00
PHST- 2015/03/04 00:00 [received]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - jev192 [pii]
AID - 10.1093/ehjci/jev192 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2016 Jun;17(6):678-86. doi: 10.1093/ehjci/jev192. 
      Epub 2015 Aug 4.