PMID- 26246060
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20181202
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 159
DP  - 2015
TI  - [Severe inflammation during recovery from neutropenia: the immune reconstitution 
      inflammatory syndrome following chemotherapy].
PG  - A8968
AB  - Immune reconstitution inflammatory syndrome (IRIS) occurs when a patient is 
      recovering from a transient immunodeficiency and results in an uncontrolled 
      inflammatory response to infectious agents and tissue damage. Symptoms such as 
      fever and radiological signs seem to paradoxically appear or worsen, unmasking a 
      previously unrecognized infection. The patient's clinical condition may then 
      deteriorate as a result of increasing tissue damage and this may even lead to 
      death. IRIS was initially described in patients suffering from a HIV infection 
      who experienced immune recovery following the initiation of antiretroviral 
      therapy. Increasingly, however, the syndrome is being reported in patients who 
      are recovering from an episode of neutropenia following chemotherapy, 
      hypomethylating agent use or a stem cell transplantation for the treatment of a 
      solid tumour or haematological cancers. We describe two cases of IRIS following 
      an episode of neutropenia in patients with a haematological malignancy and 
      elaborate on the pathogenesis, diagnosis and treatment of IRIS in cancer 
      patients.
FAU - van Lier, Dirk P T
AU  - van Lier DP
AD  - Radboudumc, Nijmegen.
FAU - Janssen, Nico A F
AU  - Janssen NA
FAU - Snoeren, Miranda M
AU  - Snoeren MM
FAU - Verweij, Paul E
AU  - Verweij PE
FAU - Blijlevens, Nicole M A
AU  - Blijlevens NM
FAU - van der Velden, Walter J F M
AU  - van der Velden WJ
LA  - dut
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Ernstige inflammatie tijdens herstel van neutropenia: het 
      immuunreconstitutie-inflammatoir-syndroom na chemotherapie.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
RN  - 0 (Antineoplastic Agents)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects/therapeutic use
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/drug therapy
MH  - Inflammation/diagnosis/drug therapy
MH  - Leukemia, Myeloid, Acute/drug therapy
MH  - Middle Aged
MH  - Neutropenia/etiology/*immunology
MH  - Prednisolone/*therapeutic use
MH  - Treatment Outcome
EDAT- 2015/08/08 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/08/07 06:00
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2015;159:A8968.