PMID- 26246238 OWN - NLM STAT- MEDLINE DCOM- 20160215 LR - 20181202 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 13 DP - 2015 Aug 6 TI - Differences in utility scores obtained through Brazilian and UK value sets: a cross-sectional study. PG - 119 LID - 10.1186/s12955-015-0318-1 [doi] LID - 119 AB - BACKGROUND: Multiple sclerosis (MS) is a chronic disease associated with several impacts; especially regarding patients' health-related quality of life (HRQL). EuroQol 5 Dimensions questionnaire (EQ-5D) provides self-reported analysis of HRQL and utility scores. Although the British algorithm to convert EQ-5D responses into utility is the most used in the literature, national settings is more appropriate for health policy decision makers. A Brazilian algorithm is available, but not used in MS patients yet. Primarily, this study aimed to address potential differences in utility scores obtained through Brazilian and British value sets. Secondary objective was to determine the role of disability, fatigue and patients socio-demographic and clinical characteristics relevant to MS on the utility scores reported by Brazilian patients. METHODS: Cross-sectional study with MS patients treated in 8 Brazilian sites. Patients were interviewed about socio-demographic and clinical characteristics, self-reported disability level, HRQL and impact of fatigue on daily living. Disability level, HRQL and impact of fatigue were assessed using the Expanded Disability Status Scale (EDSS) and the Brazilian versions of EQ-5D-3 L and Modified Fatigue Impact Scale (MFIS-BR), respectively. Patients were classified in subgroups according to EDSS (mild: 0-3; moderate: 4-6.5; severe: >7) and the self-perceived impact of fatigue (absent: /= 59). EQ-5D-3 L data was converted into a utility index using an algorithm developed by a Brazilian research group (QALY Brazil) and also the UK algorithm. Differences between utility scores were analysed through Wilcoxon test. RESULTS: Two hundred and ten patients were included in the study. Utility index mean scores of 0.59 (SD = 0.22) and 0.56 (SD = 0.32) for the Brazilian and UK algorithms were observed, respectively, without statistically significant difference for the distribution of data (p = 0.586). However, when utility scores were lower than 0.5, Brazilian algorithm provided higher estimates than UK with a better agreement between the scores found closer to 1. The same trend was observed when data was stratified for EDSS and impact of fatigue, with statistically significant difference between scores in categories of mild/severe disabilities and absent/high impact of fatigue. CONCLUSIONS: Results suggest that Brazilian value set provided higher utility scores than the UK, particularly for measures below 0.5. FAU - Takemoto, Maira Libertad Soligo AU - Takemoto ML AD - ANOVA - Avaliacao de Tecnologia em Saude, Rua da Ajuda, 35, sala 704 - 7 degrees andar Centro, Rio de Janeiro, RJ, Brazil. maira.takemoto@anova.org.br. FAU - Lopes da Silva, Nilceia AU - Lopes da Silva N AD - Novartis Biociencias S.A., Avenida Prof. Vicente Rao, 90, Sao Paulo, SP, Brazil. nilceia.lopes@novartis.com. FAU - Ribeiro-Pereira, Ana Carolina Padula AU - Ribeiro-Pereira AC AD - ANOVA - Avaliacao de Tecnologia em Saude, Rua da Ajuda, 35, sala 704 - 7 degrees andar Centro, Rio de Janeiro, RJ, Brazil. carolina.padula@anova.org.br. FAU - Schilithz, Arthur Orlando Correa AU - Schilithz AO AD - ANOVA - Avaliacao de Tecnologia em Saude, Rua da Ajuda, 35, sala 704 - 7 degrees andar Centro, Rio de Janeiro, RJ, Brazil. arthur.schilithz@anova.org.br. FAU - Suzuki, Cibele AU - Suzuki C AD - Novartis Biociencias S.A., Avenida Prof. Vicente Rao, 90, Sao Paulo, SP, Brazil. cibele.suzuki@novartis.com. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150806 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM MH - Adaptation, Psychological MH - Adult MH - Algorithms MH - Brazil MH - Cross-Sectional Studies MH - Fatigue MH - Female MH - Humans MH - Male MH - Middle Aged MH - Multiple Sclerosis/*psychology/therapy MH - Pain Measurement/statistics & numerical data MH - Psychometrics/statistics & numerical data MH - Quality of Life/*psychology MH - Reproducibility of Results MH - *Severity of Illness Index MH - Surveys and Questionnaires/*standards PMC - PMC4527221 EDAT- 2015/08/08 06:00 MHDA- 2016/02/16 06:00 PMCR- 2015/08/06 CRDT- 2015/08/07 06:00 PHST- 2015/02/12 00:00 [received] PHST- 2015/07/29 00:00 [accepted] PHST- 2015/08/07 06:00 [entrez] PHST- 2015/08/08 06:00 [pubmed] PHST- 2016/02/16 06:00 [medline] PHST- 2015/08/06 00:00 [pmc-release] AID - 10.1186/s12955-015-0318-1 [pii] AID - 318 [pii] AID - 10.1186/s12955-015-0318-1 [doi] PST - epublish SO - Health Qual Life Outcomes. 2015 Aug 6;13:119. doi: 10.1186/s12955-015-0318-1.