PMID- 26246562
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20181113
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 89
IP  - 20
DP  - 2015 Oct
TI  - Global Database-Driven Assessment of HIV-1 Adaptation to the Immune Repertoires 
      of Human Populations.
PG  - 10693-5
LID - 10.1128/JVI.01355-15 [doi]
AB  - Associations between HIV-1 cytotoxic T lymphocyte (CTL) escape mutations and 
      their restricting human leukocyte antigen (HLA) alleles imply that HIV could 
      adapt to divergent HLA repertoires of human populations globally. Using publicly 
      available databases, we examine the relationship between the frequencies of 19 
      experimentally validated CTL escape mutations in HIV-1 reverse transcriptase and 
      their restricting HLA alleles in 59 countries. From these extensive data, we find 
      evidence of differential HIV adaptations to human populations at only a limited 
      number of the studied epitope sites.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Karakas, Aram
AU  - Karakas A
AD  - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
FAU - Brumme, Zabrina L
AU  - Brumme ZL
AD  - Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
FAU - Poon, Art F Y
AU  - Poon AF
AD  - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada Faculty of 
      Health Sciences, Simon Fraser University, Burnaby, Canada Department of Medicine, 
      University of British Columbia, Vancouver, Canada apoon@cfenet.ubc.ca.
LA  - eng
GR  - HOP-111406/Canadian Institutes of Health Research/Canada
GR  - HOP-115700/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150805
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
SB  - IM
MH  - Adaptation, Biological/*genetics/immunology
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Databases, Genetic
MH  - Epitopes/genetics/immunology
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HIV Infections/epidemiology/immunology/pathology/*virology
MH  - HIV Reverse Transcriptase/*genetics/immunology
MH  - HIV-1/*genetics/immunology
MH  - HLA Antigens/classification/*genetics/immunology
MH  - Humans
MH  - Immune Evasion
MH  - Molecular Sequence Data
MH  - Mutation
MH  - T-Lymphocytes, Cytotoxic/immunology/pathology/*virology
PMC - PMC4580167
EDAT- 2015/08/08 06:00
MHDA- 2015/12/17 06:00
PMCR- 2016/04/15
CRDT- 2015/08/07 06:00
PHST- 2015/05/26 00:00 [received]
PHST- 2015/07/27 00:00 [accepted]
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
PHST- 2016/04/15 00:00 [pmc-release]
AID - JVI.01355-15 [pii]
AID - 01355-15 [pii]
AID - 10.1128/JVI.01355-15 [doi]
PST - ppublish
SO  - J Virol. 2015 Oct;89(20):10693-5. doi: 10.1128/JVI.01355-15. Epub 2015 Aug 5.