PMID- 26246746
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150806
LR  - 20200929
IS  - 0973-1296 (Print)
IS  - 0976-4062 (Electronic)
IS  - 0973-1296 (Linking)
VI  - 11
IP  - 43
DP  - 2015 Jul-Sep
TI  - Quantification of maltol in Korean ginseng (Panax ginseng) products by 
      high-performance liquid chromatography-diode array detector.
PG  - 657-64
LID - 10.4103/0973-1296.160452 [doi]
AB  - BACKGROUND: Maltol, as a type of phenolic compounds, is produced by the browning 
      reaction during the high-temperature treatment of ginseng. Thus, maltol can be 
      used as a marker for the quality control of various ginseng products manufactured 
      by high-temperature treatment including red ginseng. For the quantification of 
      maltol in Korean ginseng products, an effective high-performance liquid 
      chromatography-diode array detector (HPLC-DAD) method was developed. MATERIALS 
      AND METHODS: The HPLC-DAD method for maltol quantification coupled with a 
      liquid-liquid extraction (LLE) method was developed and validated in terms of 
      linearity, precision, and accuracy. An HPLC separation was performed on a C18 
      column. RESULTS: The LLE methods and HPLC running conditions for maltol 
      quantification were optimized. The calibration curve of the maltol exhibited good 
      linearity (R (2) = 1.00). The limit of detection value of maltol was 0.26 mug/mL, 
      and the limit of quantification value was 0.79 mug/mL. The relative standard 
      deviations (RSDs) of the data of the intra- and inter-day experiments were <1.27% 
      and 0.61%, respectively. The results of the recovery test were 101.35-101.75% 
      with an RSD value of 0.21-1.65%. The developed method was applied successfully to 
      quantify the maltol in three ginseng products manufactured by different methods. 
      CONCLUSION: The results of validation demonstrated that the proposed HPLC-DAD 
      method was useful for the quantification of maltol in various ginseng products.
FAU - Jeong, Hyun Cheol
AU  - Jeong HC
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Hong, Hee-Do
AU  - Hong HD
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Kim, Young-Chan
AU  - Kim YC
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Rhee, Young Kyoung
AU  - Rhee YK
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Choi, Sang Yoon
AU  - Choi SY
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Kim, Kyung-Tack
AU  - Kim KT
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Kim, Sung Soo
AU  - Kim SS
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Lee, Young-Chul
AU  - Lee YC
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
FAU - Cho, Chang-Won
AU  - Cho CW
AD  - Ginseng Research Center, Korea Food Research Institute, Seongnam, Gyeonggi 
      463-746, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogn Mag
JT  - Pharmacognosy magazine
JID - 101300403
PMC - PMC4522857
OTO - NOTNLM
OT  - High-performance liquid chromatography-diode array detector
OT  - Panax ginseng
OT  - maltol
OT  - quantification
OT  - validation
COIS- Conflict of Interest: None declared.
EDAT- 2015/08/08 06:00
MHDA- 2015/08/08 06:01
PMCR- 2015/07/01
CRDT- 2015/08/07 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/08/13 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/08/07 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2015/08/08 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - PM-11-657 [pii]
AID - 10.4103/0973-1296.160452 [doi]
PST - ppublish
SO  - Pharmacogn Mag. 2015 Jul-Sep;11(43):657-64. doi: 10.4103/0973-1296.160452.