PMID- 26248535 OWN - NLM STAT- MEDLINE DCOM- 20160602 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 17 IP - 1 DP - 2015 Aug 7 TI - Influence of phase correction of late gadolinium enhancement images on scar signal quantification in patients with ischemic and non-ischemic cardiomyopathy. PG - 66 LID - 10.1186/s12968-015-0163-8 [doi] LID - 66 AB - BACKGROUND: Myocardial fibrosis imaging using late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) has been validated as a quantitative predictive marker for response to medical, surgical, and device therapy. To date, all such studies have examined conventional, non-phase corrected magnitude images. However, contemporary practice has rapdily adopted phase-corrected image reconstruction. We sought to investigate the existence of any systematic bias between threshold-based scar quantification performed on conventional magnitude inversion recovery (MIR) and matched phase sensitive inversion recovery (PSIR) images. METHODS: In 80 patients with confirmed ischemic (N = 40), or non-ischemic (n = 40) myocardial fibrosis, and also in a healthy control cohort (N = 40) without fibrosis, myocardial late enhancement was quantified using a Signal Threshold Versus Reference Myocardium technique (STRM) at >/=2, >/=3, and >/=5 SD threshold, and also using the Full Width at Half Maximal (FWHM) technique. This was performed on both MIR and PSIR images and values compared using linear regression and Bland-Altman analyses. RESULTS: Linear regression analysis demonstrated excellent correlation for scar volumes between MIR and PSIR images at all three STRM signal thresholds for the ischemic (N = 40, r = 0.96, 0.95, 0.88 at 2, 3, and 5 SD, p < 0.0001 for all regressions), and non ischemic (N = 40, r = 0.86, 0.89, 0.90 at 2, 3, and 5 SD, p < 0.0001 for all regressions) cohorts. FWHM analysis demonstrated good correlation in the ischemic population (N = 40, r = 0.83, p < 0.0001). Bland-Altman analysis demonstrated a systematic bias with MIR images showing higher values than PSIR for ischemic (3.3 %, 3.9 % and 4.9 % at 2, 3, and 5 SD, respectively), and non-ischemic (9.7 %, 7.4 % and 4.1 % at >/=2, >/=3, and >/=5 SD thresholds, respectively) cohorts. Background myocardial signal measured in the control population demonstrated a similar bias of 4.4 %, 2.6 % and 0.7 % of the LV volume at 2, 3 and 5 SD thresholds, respectively. The bias observed using FWHM analysis was -6.9 %. CONCLUSIONS: Scar quantification using phase corrected (PSIR) images achieves values highly correlated to those obtained on non-corrected (MIR) images. However, a systematic bias exists that appears exaggerated in non-ischemic cohorts. Such bias should be considered when comparing or translating knowledge between MIR- and PSIR-based imaging. FAU - Stirrat, John AU - Stirrat J AD - Robarts Research Institute, University of Western Ontario, London, Ontario, Canada. jstirrat@imaging.robarts.ca. FAU - Joncas, Sebastien Xavier AU - Joncas SX AD - Division of Cardiology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. Sebastien.Joncas@USherbrooke.ca. AD - Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Sebastien.Joncas@USherbrooke.ca. FAU - Salerno, Michael AU - Salerno M AD - Departments of Medicine, Radiology, and Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. MS5PC@hscmail.mcc.virginia.edu. FAU - Drangova, Maria AU - Drangova M AD - Robarts Research Institute, University of Western Ontario, London, Ontario, Canada. mdrangov@imaging.robarts.ca. AD - Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. mdrangov@imaging.robarts.ca. FAU - White, James AU - White J AD - Division of Cardiology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. jawhit@ucalgary.ca. AD - Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. jawhit@ucalgary.ca. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150807 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Bias MH - Cardiomyopathies/*diagnosis/pathology/physiopathology MH - Case-Control Studies MH - Cicatrix/*diagnosis/pathology/physiopathology MH - *Contrast Media MH - Female MH - Fibrosis MH - *Gadolinium DTPA MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - Linear Models MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardial Ischemia/*diagnosis/pathology/physiopathology MH - Myocardium/*pathology MH - *Organometallic Compounds MH - Predictive Value of Tests MH - Reproducibility of Results MH - Stroke Volume MH - Ventricular Function, Left PMC - PMC4528363 EDAT- 2015/08/08 06:00 MHDA- 2016/06/03 06:00 PMCR- 2015/08/07 CRDT- 2015/08/08 06:00 PHST- 2015/02/19 00:00 [received] PHST- 2015/06/24 00:00 [accepted] PHST- 2015/08/08 06:00 [entrez] PHST- 2015/08/08 06:00 [pubmed] PHST- 2016/06/03 06:00 [medline] PHST- 2015/08/07 00:00 [pmc-release] AID - S1097-6647(23)00891-8 [pii] AID - 163 [pii] AID - 10.1186/s12968-015-0163-8 [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2015 Aug 7;17(1):66. doi: 10.1186/s12968-015-0163-8.