PMID- 26248639
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20181202
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Linking)
VI  - 51
IP  - 74
DP  - 2015 Sep 25
TI  - The role of carrier ligands of platinum(II) anticancer complexes in the protein 
      recognition of Pt-DNA adducts.
PG  - 14064-7
LID - 10.1039/c5cc05257b [doi]
AB  - In order to systematically investigate the influence of carrier ligands on the 
      interaction of Pt-DNA adducts with damage recognition proteins, a series of DNA 
      probes containing 1,2-GG platinum compound crosslinks using cisplatin, 
      oxaliplatin, (S,S-DACH)PtCl2 and (cis-1,4-DACH)PtCl2 (kiteplatin) has been 
      constructed. These complexes share similar DNA binding properties although they 
      exhibit quite different cytotoxicity. It is revealed that HMGB1 (high-mobility 
      group protein B1) was the most commonly found protein that recognizes all 
      Pt(II)-DNA probes and prefers cisplatin-DNA probes more than the others. 
      Interestingly, an important component of the replication protein A complex, RPA2, 
      was found to bind to kiteplatin much more tightly than other proteins. These 
      results may be important for the interpretation of the roles of carrier ligands 
      in platinum(II)-based anticancer complexes.
FAU - He, Yafeng
AU  - He Y
AD  - State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, 
      State Key Laboratory of Analytical Chemistry for Life Science, School of 
      Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry 
      for Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, 210093, P. R. 
      China. chenhao@nju.edu.cn zguo@nju.edu.cn.
FAU - Yuan, Jian
AU  - Yuan J
FAU - Qiao, Yuchen
AU  - Qiao Y
FAU - Wang, Dan
AU  - Wang D
FAU - Chen, Weizhong
AU  - Chen W
FAU - Liu, Xichun
AU  - Liu X
FAU - Chen, Hao
AU  - Chen H
FAU - Guo, Zijian
AU  - Guo Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cyclohexylamines)
RN  - 0 (DNA Adducts)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drug Carriers)
RN  - 0 (Ligands)
RN  - 0 (Organoplatinum Compounds)
RN  - 0 (platinum(II)(1,4-diazacycloheptane)dichloride)
RN  - 04ZR38536J (Oxaliplatin)
RN  - C82TX76BHH (1,2-cyclohexanediamine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Agents/administration & dosage/*chemistry
MH  - Cisplatin/administration & dosage/*chemistry
MH  - Cyclohexylamines/chemistry
MH  - DNA Adducts/*chemistry
MH  - DNA-Binding Proteins/chemistry
MH  - Drug Carriers/*chemistry
MH  - Ligands
MH  - Organoplatinum Compounds/administration & dosage/*chemistry
MH  - Oxaliplatin
EDAT- 2015/08/08 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/08/08 06:00
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1039/c5cc05257b [doi]
PST - ppublish
SO  - Chem Commun (Camb). 2015 Sep 25;51(74):14064-7. doi: 10.1039/c5cc05257b.