PMID- 26248896
OWN - NLM
STAT- MEDLINE
DCOM- 20160615
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 28
IP  - 9
DP  - 2015 Sep
TI  - Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses 
      in differential diagnosis, including solid variant papillary renal cell carcinoma 
      and epithelial-predominant nephroblastoma.
PG  - 1236-48
LID - 10.1038/modpathol.2015.81 [doi]
AB  - Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with 
      the solid variant of papillary renal cell carcinoma and epithelial-predominant 
      nephroblastoma. To aid in resolving this differential diagnosis, we investigated 
      the utility of immunohistochemical and molecular analyses in distinguishing 
      between these entities; the first study, to our knowledge, to use a combined 
      approach in analyzing all three tumors. We analyzed 37 tumors originally 
      diagnosed as metanephric adenomas (2 of which we reclassified as papillary renal 
      cell carcinomas), 13 solid variant papillary renal cell carcinomas, and 20 
      epithelial-predominant nephroblastomas using a combination of 
      immunohistochemistry and fluorescence in situ hybridization (FISH) assessing for 
      trisomy of chromosomes 7 and 17 and loss of Y. Immunohistochemical staining was 
      performed for CK7, AMACR, WT1, and CD57. The combination of CK7-, AMACR-, WT1+, 
      and CD57+ was considered characteristic of metanephric adenoma. Most of the 
      tumors originally diagnosed as metanephric adenomas (31/37) showed the expected 
      staining pattern of metanephric adenoma (CK7-, AMACR-, WT1+, and CD57+). Of the 
      six tumors with discordant immunophenotype, two tumors were reclassified as 
      papillary renal cell carcinoma after cytogenetic workup. It is recommended that 
      all adult cases histologically resembling metanephric adenoma have WT1, CD57, 
      CK7, and AMACR immunohistochemical staining performed. If the staining pattern is 
      characteristic for metanephric adenoma (CK7-, AMACR-, WT1+, and CD57+, including 
      membranous staining), then no other diagnostic tests are indicated. However, if 
      there is a different immunostaining pattern, then we recommend FISH analysis.
FAU - Kinney, Stephanie N
AU  - Kinney SN
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Eble, John N
AU  - Eble JN
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Hes, Ondrej
AU  - Hes O
AD  - Department of Pathology, Charles University Hospital Plzen, Pilsen, Czech 
      Republic.
FAU - Williamson, Sean R
AU  - Williamson SR
AD  - Department of Pathology and Laboratory Medicine, Henry Ford Health System, 
      Detroit, MI, USA.
FAU - Grignon, David J
AU  - Grignon DJ
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Wang, Mingsheng
AU  - Wang M
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Zhang, Shaobo
AU  - Zhang S
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Baldrige, Lee Ann
AU  - Baldrige LA
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Martignoni, Guido
AU  - Martignoni G
AD  - Dipartimento di Patologia, Universita di Verona, Verona, Italy.
FAU - Brunelli, Matteo
AU  - Brunelli M
AD  - Dipartimento di Patologia, Universita di Verona, Verona, Italy.
FAU - Wang, Lisha
AU  - Wang L
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      China.
FAU - Comperat, Eva
AU  - Comperat E
AD  - Department of Pathology, Groupe Hospitalier Pitie-Salpetriere, Paris, France.
FAU - Fan, Rong
AU  - Fan R
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Montironi, Rodolfo
AU  - Montironi R
AD  - Department of Pathological Anatomy and Histopathology, School of Medicine, 
      Polytechnic University of the Marche Region (Ancona), Ancona, Italy.
FAU - MacLennan, Gregory T
AU  - MacLennan GT
AD  - Department of Pathology and Laboratory Medicine, Case Western Reserve University, 
      Cleveland, OH, USA.
FAU - Cheng, Liang
AU  - Cheng L
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
LA  - eng
PT  - Journal Article
DEP - 20150807
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenoma/*diagnosis
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Renal Cell/diagnosis
MH  - Child
MH  - Cytogenetic Analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Wilms Tumor/diagnosis
MH  - Young Adult
EDAT- 2015/08/08 06:00
MHDA- 2016/06/16 06:00
CRDT- 2015/08/08 06:00
PHST- 2014/02/18 00:00 [received]
PHST- 2015/03/04 00:00 [revised]
PHST- 2015/05/29 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/06/16 06:00 [medline]
AID - S0893-3952(22)01379-5 [pii]
AID - 10.1038/modpathol.2015.81 [doi]
PST - ppublish
SO  - Mod Pathol. 2015 Sep;28(9):1236-48. doi: 10.1038/modpathol.2015.81. Epub 2015 Aug 
      7.