PMID- 26250401
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20220330
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 5
IP  - 12
DP  - 2015 Dec
TI  - Can serum white birch (Betula verrucosa) pollen antigen (Bet v 1) immunoglobulin 
      E measurement distinguish between sensitization and allergy?
PG  - 1151-5
LID - 10.1002/alr.21612 [doi]
AB  - BACKGROUND: In clinical practice, it is fundamental to distinguish between 
      sensitization and allergy, mainly with respect to polysensitized patients. The 
      aim of this study was to evaluate whether serum immunoglobulin E (IgE) to white 
      birch (Betula verrucosa) pollen antigen (Bet v 1) assessment might be able to 
      differentiate simple sensitization from true allergy. METHODS: In total, 197 
      subjects (100 females; mean age 44.9 years) with serum Bet v 1 IgE positivity and 
      history of nasal symptoms were evaluated. Subjects were subdivided in 2 groups: 
      allergic and sensitized. RESULTS: Allergic patients were 58.4% of the total; they 
      had higher serum Bet v 1 IgE levels than sensitized subjects (p < 0.001). A serum 
      IgE to Bet v 1 value >8.94 kilo units of allergen per liter (kUA/L) was able to 
      differentiate between sensitization and allergy (area under the receiver 
      operating characteristic curve [AUC] = 0.76; diagnostic odds ratio, ie, degree of 
      agreement between health status and dichotomized IgE levels [DOR] = 6.5). Gender 
      and season when the blood was drawn influenced IgE levels. CONCLUSION: Serum Bet 
      v 1 IgE measurement may be able to differentiate sensitization from allergy in 
      subjects with sensitization to Betulaceae pollen allergens. Thus, Bet v 1 IgE 
      measurement should be considered a useful step in the management of patients with 
      allergic rhinitis due to Betulaceae pollen allergens.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Ciprandi, Giorgio
AU  - Ciprandi G
AD  - Allergy Department, National Institute For Cancer Research-University Hospital, 
      Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera 
      Universitaria (IRCCS-AOU) San Martino, Genoa, Italy.
FAU - Comite, Paola
AU  - Comite P
AD  - Department of Laboratory Medicine, IRCCS-AOU San Martino, Genoa, Italy.
FAU - Ferrero, Francesca
AU  - Ferrero F
AD  - Department of Laboratory Medicine, IRCCS-AOU San Martino, Genoa, Italy.
FAU - Minale, Paola
AU  - Minale P
AD  - Allergy Department, National Institute For Cancer Research-University Hospital, 
      Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera 
      Universitaria (IRCCS-AOU) San Martino, Genoa, Italy.
FAU - Voltolini, Susanna
AU  - Voltolini S
AD  - Allergy Department, National Institute For Cancer Research-University Hospital, 
      Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera 
      Universitaria (IRCCS-AOU) San Martino, Genoa, Italy.
FAU - Bignardi, Donatella
AU  - Bignardi D
AD  - Allergy Department, National Institute For Cancer Research-University Hospital, 
      Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera 
      Universitaria (IRCCS-AOU) San Martino, Genoa, Italy.
FAU - Fontana, Vincenzo
AU  - Fontana V
AD  - Clinical Epidemiology Unit; IRCCS-AOU San Martino, Genoa, Italy.
FAU - Bruzzone, Marco
AU  - Bruzzone M
AD  - Clinical Epidemiology Unit; IRCCS-AOU San Martino, Genoa, Italy.
FAU - Troise, Costantino
AU  - Troise C
AD  - Allergy Department, National Institute For Cancer Research-University Hospital, 
      Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera 
      Universitaria (IRCCS-AOU) San Martino, Genoa, Italy.
FAU - Mussap, Michele
AU  - Mussap M
AD  - Department of Laboratory Medicine, IRCCS-AOU San Martino, Genoa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150806
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 126161-14-6 (Bet v 1 allergen, Betula)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Antigens, Plant/*immunology
MH  - Betula/immunology
MH  - Cross Reactions
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Seasonal/*diagnosis/immunology
MH  - Skin Tests
OTO - NOTNLM
OT  - Bet v 1
OT  - allergic rhinitis
OT  - allergy
OT  - sensitization
OT  - serum IgE
EDAT- 2015/08/08 06:00
MHDA- 2016/12/30 06:00
CRDT- 2015/08/08 06:00
PHST- 2015/03/26 00:00 [received]
PHST- 2015/05/29 00:00 [revised]
PHST- 2015/06/26 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/12/30 06:00 [medline]
AID - 10.1002/alr.21612 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2015 Dec;5(12):1151-5. doi: 10.1002/alr.21612. Epub 
      2015 Aug 6.