PMID- 26250415
OWN - NLM
STAT- MEDLINE
DCOM- 20160107
LR  - 20181113
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 15
DP  - 2015 Aug 7
TI  - Postoperative anatomical and functional outcomes of different stages of high 
      myopia macular hole.
PG  - 93
LID - 10.1186/s12886-015-0098-8 [doi]
LID - 93
AB  - BACKGROUND: Recently it was suggested that high myopia macular holes (HMMH) and 
      macular holes accompanied by retinal detachment occur in the advanced stages of 
      myopia traction maculopathy (MTM), while macular retinoschisis, shallow retinal 
      detachment without holes, and lamellar macular holes occur in the early stages of 
      MTM. Complete vitreous cortex removal associated with internal limiting membrane 
      peeling is now widely used to treat HMMH. However, it remains uncertain at what 
      HMMH stage patients would benefit most from surgical intervention. Our study was 
      aimed to evaluate the postoperative anatomical changes and functional outcomes of 
      high myopia macular holes (HMMH). METHODS: Patients were retrospectively 
      collected between March 2009 and August 2011. Before and 1st, 3rd, and 9th month 
      after 23G pars plana vitrectomy, all patients underwent a complete ophthalmologic 
      examination, spectral domain optical coherence tomography (SD-OCT) and MP-1. At 
      each follow-up, best-corrected visual acuity (BCVA), photoreceptor inner and 
      outer segments (IS/OS) defects, and retinal sensitivity (RS) were investigated. 
      According to different preoperative macular hole morphologies, patients were 
      divided into three groups: Group 1, macular hole with epiretinal membrane (ERM) 
      traction and macular retinoschisis; Group 2, full-thickness macular hole (FTMH); 
      Group 3, FTMH with subretinal fluid. RESULTS: 43 eyes from 43 patients met the 
      inclusion criteria. The mean age was 60 years. BCVA and RS were significantly 
      improved after vitrectomy; the mean IS/OS defect was significantly reduced. At 9 
      postoperative months, 11 of 43 (25.6 %) eyes achieved IS/OS junction integrity; 9 
      of these 11 (81.8 %) eyes belonged to Group 1, 2 (18.2 %) belonged to Group 2. 
      CONCLUSIONS: Pars plana vitrectomy combined with ILM peeling and gas tamponade 
      results in limited functional outcomes in patients with HMMH. The appearance of 
      subretinal fluid indicates a worse prognosis for surgical intervention.
FAU - Shao, Qing
AU  - Shao Q
AD  - Department of Ophthalmology, Shanghai First People's Hospital, Haining Road 100, 
      200080, Shanghai, China. qshao87@hotmail.com.
AD  - Department of Ophthalmology, Charite-Universitatsmedizin, Berlin, Germany. 
      qshao87@hotmail.com.
FAU - Xia, Huijuan
AU  - Xia H
AD  - Department of Ophthalmology, Shanghai First People's Hospital, Haining Road 100, 
      200080, Shanghai, China. huijuanxia2015@sina.com.
FAU - Heussen, Florian M A
AU  - Heussen FM
AD  - Department of Ophthalmology, The Royal Liverpool University Hospital, Liverpool, 
      UK. florian.heussen@gmail.com.
FAU - Ouyang, Yanling
AU  - Ouyang Y
AD  - Department of Ophthalmology, Charite-Universitatsmedizin, Berlin, Germany. 
      yanlingyouyang@gmail.com.
FAU - Sun, Xiaodong
AU  - Sun X
AD  - Department of Ophthalmology, Shanghai First People's Hospital, Haining Road 100, 
      200080, Shanghai, China. xdsun@sjtu.edu.cn.
FAU - Fan, Ying
AU  - Fan Y
AD  - Department of Ophthalmology, Shanghai First People's Hospital, Haining Road 100, 
      200080, Shanghai, China. mdyingfan@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150807
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Aged
MH  - Endotamponade
MH  - Epiretinal Membrane/surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia, Degenerative/*physiopathology/surgery
MH  - Postoperative Period
MH  - Retina/*physiopathology
MH  - Retinal Perforations/*physiopathology/surgery
MH  - Retrospective Studies
MH  - Subretinal Fluid
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
MH  - Visual Field Tests
MH  - Vitrectomy
PMC - PMC4527123
EDAT- 2015/08/08 06:00
MHDA- 2016/01/08 06:00
PMCR- 2015/08/07
CRDT- 2015/08/08 06:00
PHST- 2015/01/14 00:00 [received]
PHST- 2015/07/31 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/01/08 06:00 [medline]
PHST- 2015/08/07 00:00 [pmc-release]
AID - 10.1186/s12886-015-0098-8 [pii]
AID - 98 [pii]
AID - 10.1186/s12886-015-0098-8 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2015 Aug 7;15:93. doi: 10.1186/s12886-015-0098-8.