PMID- 26250540
OWN - NLM
STAT- MEDLINE
DCOM- 20160808
LR  - 20150921
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Linking)
VI  - 28
IP  - 9
DP  - 2015 Sep 21
TI  - Pathophysiological insights of methylglyoxal induced type-2 diabetes.
PG  - 1666-74
LID - 10.1021/acs.chemrestox.5b00171 [doi]
AB  - Diabetes mellitus is a metabolic disorder constituting a major health problem 
      whose prevalence has gradually increased worldwide over the past few decades. 
      Type 2 diabetes mellitus (T2DM) remains more complex and heterogeneous and arises 
      as a combination of insulin resistance and inadequate functional beta-cell mass and 
      comprises about 90% of all diabetic cases. Appropriate experimental animal models 
      are essential for understanding the molecular basis, pathogenesis of 
      complications, and the utility of therapeutic agents to abrogate this 
      multifaceted disorder. Currently, animal models for T2DM are obtained as 
      spontaneously developed diabetes or diabetes induced by chemicals or dietary 
      manipulations or through surgical or genetic methods. The currently used 
      diabetogenic agents have certain limitations. Recently, methylglyoxal (MG), a 
      highly reactive compound derived mainly from glucose and fructose metabolism has 
      been implicated in diabetic complications. MG is a major precursor of the 
      advanced glycation end product (AGE) and promotes impaired functions of insulin 
      signaling, GLUT transporters, anion channels, kinases, and endothelial cells and 
      is finally involved in apoptosis. Recent array of literature also cited that 
      higher concentrations of MG causes rapid depolarization, elevated intracellular 
      Ca(2+) concentration, and acidification in pancreatic beta-cells. This review 
      henceforth highlights the mechanism of action of MG and its implications in the 
      pathophysiology of experimental diabetes.
FAU - Dornadula, Sireesh
AU  - Dornadula S
AD  - SRM Research Institute, SRM University , Kattankulathur-603 203, Tamilnadu, 
      India.
FAU - Elango, Bhakkiyalakshmi
AU  - Elango B
AD  - SRM Research Institute, SRM University , Kattankulathur-603 203, Tamilnadu, 
      India.
FAU - Balashanmugam, Ponjayanthi
AU  - Balashanmugam P
AD  - SRM Research Institute, SRM University , Kattankulathur-603 203, Tamilnadu, 
      India.
FAU - Palanisamy, Rajaguru
AU  - Palanisamy R
AD  - Department of Biotechnology, Anna University-BIT Campus , Tiruchirappalli-620 
      024, Tamilnadu, India.
FAU - Kunka Mohanram, Ramkumar
AU  - Kunka Mohanram R
AD  - SRM Research Institute, SRM University , Kattankulathur-603 203, Tamilnadu, 
      India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150911
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 722KLD7415 (Pyruvaldehyde)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*chemically induced/physiopathology
MH  - *Disease Models, Animal
MH  - Pyruvaldehyde/*adverse effects/chemical synthesis
EDAT- 2015/08/08 06:00
MHDA- 2016/08/09 06:00
CRDT- 2015/08/08 06:00
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/08/09 06:00 [medline]
AID - 10.1021/acs.chemrestox.5b00171 [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2015 Sep 21;28(9):1666-74. doi: 10.1021/acs.chemrestox.5b00171. 
      Epub 2015 Sep 11.