PMID- 26250880
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20181202
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 35
IP  - 8
DP  - 2016 Nov
TI  - Age-related changes in bladder function with altered angiotensin II receptor 
      mechanisms in rats.
PG  - 908-913
LID - 10.1002/nau.22849 [doi]
AB  - AIMS: To examine alterations in expression of angiotensin II type 1 receptors 
      (AT1R) which induce organ tissue remodeling, angiotensin II type 2 receptors 
      (AT2R) which protect against it, and related molecules in the bladder of matured 
      rats with bladder dysfunction. METHODS: Female SD rats of three different ages 
      were used: 8 weeks old (8W; n = 5), 9 months old (9M; n = 5), and 15 months old 
      (15M; n = 5). After cystometry, the expression levels of AT1R, connexin43 (Cx43), 
      MAP kinase (MAPK), collagen1, AT2R, PPAR-gamma, adiponectin (Adipo), and adiponectin 
      receptor (Adipo-R) were investigated in the bladder. RESULTS: Pressure threshold, 
      post-void residual volume and the number of non-voiding contractions were 
      significantly increased in 15M versus 8W rats (P < 0.01). Maximum voiding 
      pressure was significantly decreased in 15M versus 8W rats (P < 0.05). There was 
      no significant difference in CMG parameters between 8W and 9M rats. In the 
      bladder, the mRNA expression of AT1R, Cx43, MAPK, collagen 1, AT2R, PPAR-gamma, 
      Adipo, and Adipo-R were significantly higher in 15M than in 8W rats. The relative 
      expression ratio of AT1R protein against AT2R protein in the mucosa and detrusor 
      was significantly increased in 15M versus 8W rats. CONCLUSIONS: These results 
      indicate that matured rats exhibit not only bladder overactivity but also 
      impaired voiding, which are associated with upregulation of AT1R. The 
      upregulation of AT2R also may play a significant role in the suppressing of AT1R 
      induced remodelling. However, because AT1R upregulation is more dominant than 
      AT2R increases, AT2R activation may not be sufficient to suppress AT1R 
      stimulation in matured rats. Neurourol. Urodynam. 35:908-913, 2016. (c) 2015 Wiley 
      Periodicals, Inc.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Mori, Kenichi
AU  - Mori K
AD  - Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
AD  - Department of Urology, Oita University Faculty of Medicine, Oita, Japan.
FAU - Noguchi, Mitsuru
AU  - Noguchi M
AD  - Department of Urology, Saga University Faculty of Medicine, Saga, Japan.
FAU - Tobu, Shohei
AU  - Tobu S
AD  - Department of Urology, Saga University Faculty of Medicine, Saga, Japan.
FAU - Sato, Fuminori
AU  - Sato F
AD  - Department of Urology, Oita University Faculty of Medicine, Oita, Japan.
FAU - Mimata, Hiromitsu
AU  - Mimata H
AD  - Department of Urology, Oita University Faculty of Medicine, Oita, Japan.
FAU - Tyagi, Pradeep
AU  - Tyagi P
AD  - Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
FAU - Chancellor, Michael B
AU  - Chancellor MB
AD  - Department of Urology, Oakland University William Beaumont School of Medicine, 
      Royal Oak, Michigan.
FAU - Yoshimura, Naoki
AU  - Yoshimura N
AD  - Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania. nyos@pitt.edu.
LA  - eng
GR  - R01 DK088836/DK/NIDDK NIH HHS/United States
GR  - P01 DK093424/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20150807
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
RN  - 0 (Biomarkers)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Receptor, Angiotensin, Type 2)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Female
MH  - In Vitro Techniques
MH  - Mucous Membrane/drug effects/metabolism
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects/metabolism
MH  - Pressure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Angiotensin, Type 1/drug effects
MH  - Receptor, Angiotensin, Type 2/*drug effects
MH  - Urinary Bladder/*drug effects/growth & development/*physiology
MH  - Urinary Bladder, Overactive/physiopathology
MH  - Urination
OTO - NOTNLM
OT  - aging
OT  - angiotensin II receptor
OT  - bladder dysfunction
OT  - gap junction
EDAT- 2015/08/08 06:00
MHDA- 2018/01/06 06:00
CRDT- 2015/08/08 06:00
PHST- 2015/05/24 00:00 [received]
PHST- 2015/07/22 00:00 [accepted]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2015/08/08 06:00 [entrez]
AID - 10.1002/nau.22849 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2016 Nov;35(8):908-913. doi: 10.1002/nau.22849. Epub 2015 Aug 
      7.