PMID- 26251006
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20181113
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 116
IP  - 7
DP  - 2015 Oct 1
TI  - Diagnostic Accuracy of Cardiac Magnetic Resonance Imaging in the Evaluation of 
      Newly Diagnosed Heart Failure With Reduced Left Ventricular Ejection Fraction.
PG  - 1082-7
LID - S0002-9149(15)01609-4 [pii]
LID - 10.1016/j.amjcard.2015.06.032 [doi]
AB  - The aim of this study was to determine the diagnostic value of cardiac magnetic 
      resonance (CMR) imaging with late gadolinium enhancement (LGE), cine imaging, and 
      resting first-pass perfusion (FPP) in the evaluation for ischemic (IC) versus 
      nonischemic (NIC) cardiomyopathy in new-onset heart failure with reduced (</=40%) 
      left ventricular ejection fraction (HFrEF). A retrospective chart review analysis 
      identified 83 patients from January 2009 to June 2012 referred for CMR imaging 
      evaluation for new-onset HFrEF with coronary angiography performed within 
      6 months of CMR. The diagnosis of IC was established using Felker criteria on 
      coronary angiography. CMR sequences were evaluated for the presence of patterns 
      suggestive of severe underlying coronary artery disease as the cause of HFrEF 
      (subendocardial and/or transmural LGE, regional wall motion abnormality on cine, 
      regional hypoperfusion defect on resting FPP). Discriminative power was assessed 
      using receiver operator characteristics curve analysis. Coronary angiography 
      identified 36 patients (43%) with IC. Presence of subendocardial and/or 
      transmural LGE alone demonstrated good discriminative power (C-statistic 0.85, 
      95% confidence interval 0.76 to 0.94) for the diagnosis of IC. The presence of an 
      ischemic pattern on both LGE and cine sequences resulted in a specificity of 87% 
      for the diagnosis of IC, whereas the absence of an ischemic pattern on both LGE 
      and cine sequences resulted in a specificity of 94% for the diagnosis of NIC. 
      Addition of resting FPP on a subset of patients did not improve diagnostic 
      values. In conclusion, CMR has potential value in the diagnostic evaluation of IC 
      versus NIC.
CI  - Published by Elsevier Inc.
FAU - Won, Eugene
AU  - Won E
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Medicine, Section of Cardiology, VA 
      New York Harbor Health Care Center, New York, New York.
FAU - Donnino, Robert
AU  - Donnino R
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Medicine, Section of Cardiology, VA 
      New York Harbor Health Care Center, New York, New York; Department of Radiology, 
      New York University School of Medicine, New York, New York.
FAU - Srichai, Monvadi B
AU  - Srichai MB
AD  - Division of Cardiology, Department of Medicine, Medstar Georgetown University 
      Hospital, Washington, DC.
FAU - Sedlis, Steven P
AU  - Sedlis SP
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Medicine, Section of Cardiology, VA 
      New York Harbor Health Care Center, New York, New York.
FAU - Feit, Frederick
AU  - Feit F
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York.
FAU - Rolnitzky, Linda
AU  - Rolnitzky L
AD  - Division of Biostatistics, Department of Population Health, New York University 
      School of Medicine, New York, New York.
FAU - Miller, Louis H
AU  - Miller LH
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Medicine, Section of Cardiology, VA 
      New York Harbor Health Care Center, New York, New York.
FAU - Iqbal, Sohah N
AU  - Iqbal SN
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York.
FAU - Axel, Leon
AU  - Axel L
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Radiology, New York University School 
      of Medicine, New York, New York.
FAU - Nguyen, Brian
AU  - Nguyen B
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York.
FAU - Slater, James
AU  - Slater J
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York.
FAU - Shah, Binita
AU  - Shah B
AD  - Division of Cardiology, Department of Medicine, New York University School of 
      Medicine, New York, New York; Department of Medicine, Section of Cardiology, VA 
      New York Harbor Health Care Center, New York, New York. Electronic address: 
      binita.shah@nyumc.org.
LA  - eng
GR  - UL1 TR001445/TR/NCATS NIH HHS/United States
GR  - KL2 TR000053/TR/NCATS NIH HHS/United States
GR  - UL1TR000038/TR/NCATS NIH HHS/United States
GR  - KL2 RR029891/RR/NCRR NIH HHS/United States
GR  - UL1 TR000038/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20150716
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
CIN - Am J Cardiol. 2016 Feb 1;117(3):489. PMID: 26708688
CIN - Am J Cardiol. 2016 Feb 1;117(3):488-9. PMID: 26708690
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/complications/*diagnosis/physiopathology
MH  - Heart Ventricles/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Stroke Volume/*physiology
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/complications/*diagnosis/physiopathology
MH  - *Ventricular Function, Left
PMC - PMC4567940
MID - NIHMS713128
EDAT- 2015/08/08 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/10/01
CRDT- 2015/08/08 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2015/06/18 00:00 [revised]
PHST- 2015/06/18 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - S0002-9149(15)01609-4 [pii]
AID - 10.1016/j.amjcard.2015.06.032 [doi]
PST - ppublish
SO  - Am J Cardiol. 2015 Oct 1;116(7):1082-7. doi: 10.1016/j.amjcard.2015.06.032. Epub 
      2015 Jul 16.