PMID- 26251510
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20181113
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 119
IP  - 7
DP  - 2015 Oct 1
TI  - Effect of carbohydrate feeding on the bone metabolic response to running.
PG  - 824-30
LID - 10.1152/japplphysiol.00241.2015 [doi]
AB  - Bone resorption is increased after running, with no change in bone formation. 
      Feeding during exercise might attenuate this increase, preventing associated 
      problems for bone. This study investigated the immediate and short-term bone 
      metabolic responses to carbohydrate (CHO) feeding during treadmill running. Ten 
      men completed two 7-day trials, once being fed CHO (8% glucose immediately 
      before, every 20 min during, and immediately after exercise at a rate of 0.7 g 
      CHO . kg body mass(-1) . h(-1)) and once being fed placebo (PBO). On day 4 of 
      each trial, participants completed a 120-min treadmill run at 70% of maximal 
      oxygen consumption (V̇o2 max). Blood was taken at baseline (BASE), immediately 
      after exercise (EE), after 60 (R1) and 120 (R2) min of recovery, and on three 
      follow-up days (FU1-FU3). Markers of bone resorption [COOH-terminal telopeptide 
      region of collagen type 1 (beta-CTX)] and formation [NH2-terminal propeptides of 
      procollagen type 1 (P1NP)] were measured, along with osteocalcin (OC), 
      parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate, 
      glucagon-like peptide-2 (GLP-2), interleukin-6 (IL-6), insulin, cortisol, leptin, 
      and osteoprotogerin (OPG). Area under the curve was calculated in terms of the 
      immediate (BASE, EE, R1, and R2) and short-term (BASE, FU1, FU2, and FU3) 
      responses to exercise. beta-CTX, P1NP, and IL-6 responses to exercise were 
      significantly lower in the immediate postexercise period with CHO feeding 
      compared with PBO (beta-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although 
      there was no difference in the short-term response (beta-CTX: P = 0.856; P1NP: P = 
      0.721; IL-6: P = 0.327). No other variable was significantly affected by CHO 
      feeding during exercise. We conclude that CHO feeding during exercise attenuated 
      the beta-CTX and P1NP responses in the hours but not days following exercise, 
      indicating an acute effect of CHO feeding on bone turnover.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Sale, Craig
AU  - Sale C
AD  - Musculoskeletal Physiology Research Group, Sport, Health and Performance 
      Enhancement Research Centre, School of Science and Technology, Nottingham Trent 
      University, Nottingham, United Kingdom; craig.sale@ntu.ac.uk.
FAU - Varley, Ian
AU  - Varley I
AD  - Musculoskeletal Physiology Research Group, Sport, Health and Performance 
      Enhancement Research Centre, School of Science and Technology, Nottingham Trent 
      University, Nottingham, United Kingdom;
FAU - Jones, Thomas W
AU  - Jones TW
AD  - Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United 
      Kingdom;
FAU - James, Ruth M
AU  - James RM
AD  - Musculoskeletal Physiology Research Group, Sport, Health and Performance 
      Enhancement Research Centre, School of Science and Technology, Nottingham Trent 
      University, Nottingham, United Kingdom;
FAU - Tang, Jonathan C Y
AU  - Tang JC
AD  - Norwich Medical School, University of East Anglia, Norwich, United Kingdom;
FAU - Fraser, William D
AU  - Fraser WD
AD  - Norwich Medical School, University of East Anglia, Norwich, United Kingdom; 
      Norfolk and Norwich University Hospital, Norwich, United Kingdom; and.
FAU - Greeves, Julie P
AU  - Greeves JP
AD  - Department of Occupational Medicine, HQ Army Recruiting and Training Division, 
      Upavon, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150806
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type I N-terminal peptide)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Bone Resorption/blood
MH  - Bone and Bones/*drug effects/*metabolism
MH  - Calcium/metabolism
MH  - Collagen Type I/metabolism
MH  - Dietary Carbohydrates/*pharmacology
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Oxygen Consumption/drug effects
MH  - Peptide Fragments/metabolism
MH  - Procollagen/metabolism
MH  - Running/*physiology
MH  - Young Adult
PMC - PMC4593812
OTO - NOTNLM
OT  - bone metabolism
OT  - carbohydrate
OT  - exercise
OT  - feeding
OT  - running
EDAT- 2015/08/08 06:00
MHDA- 2016/07/14 06:00
PMCR- 2015/08/06
CRDT- 2015/08/08 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/07/30 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
PHST- 2015/08/06 00:00 [pmc-release]
AID - japplphysiol.00241.2015 [pii]
AID - JAPPL-00241-2015 [pii]
AID - 10.1152/japplphysiol.00241.2015 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2015 Oct 1;119(7):824-30. doi: 
      10.1152/japplphysiol.00241.2015. Epub 2015 Aug 6.