PMID- 26252073 OWN - NLM STAT- MEDLINE DCOM- 20161229 LR - 20170113 IS - 1541-1087 (Electronic) IS - 0731-5724 (Linking) VI - 35 IP - 3 DP - 2016 TI - Seafood Allergy, Toxicity, and Intolerance: A Review. PG - 271-83 LID - 10.1080/07315724.2015.1014120 [doi] AB - Seafood allergies have been increasing their presence in the last 2 decades. Allergic reactions to seafood can range from mild urticarial and oral allergy syndrome to life-threatening anaphylactic reactions. Ingestion of seafood infested with Anisakis larvae can cause a disease known as anisakiasis with symptoms similar to true seafood allergy. Furthermore, some adverse reactions to seafood including histamine fish poisoning (HFP), and intolerance to histamine can trigger clinical symptoms, which, although nonallergic in origin, are similar to true immunoglobulin E (IgE)-mediated allergic reactions. Because seafood allergy usually remains a lifelong food allergy, this review focuses on the current knowledge on fish and shellfish allergens and emphasizes the importance of differentiating seafood allergy from other allergy-like reactions (anisakiasis, HFP, and intolerance to histamine). Key teaching points: * Fish and shellfish are potent allergens that can provoke serious IgE antibody-mediated adverse reactions in sensitive individuals. * Sensitization to seafood allergens can be achieved by ingestion, inhalation, or skin contact. * Shellfish major allergen, tropomyosin, shares significant homology to arthropods (dust mites and cockroaches). * Accidental exposures to seafood products cross-contaminated with fish or shellfish allergens (hidden allergens) during processing may present a health risk for sensitive individuals. * Allergens of fish parasite A. simplex present common hidden allergens in seafood, particularly in raw and undercooked home-made fish dishes. * Symptoms caused by HFP, histamine intolerance, and anisakiasis are similar to true seafood allergy. FAU - Prester, Ljerka AU - Prester L AD - a Institute for Medical Research and Occupational Health , Zagreb , CROATIA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20150807 PL - United States TA - J Am Coll Nutr JT - Journal of the American College of Nutrition JID - 8215879 SB - IM MH - Animals MH - *Arthropods MH - *Fishes MH - *Food Hypersensitivity MH - Humans MH - *Mollusca MH - Seafood/*toxicity OTO - NOTNLM OT - A. simplex OT - cross-reactive allergens OT - fish allergy OT - hidden allergens OT - histamine fish poisoning OT - shellfish allergy EDAT- 2015/08/08 06:00 MHDA- 2016/12/31 06:00 CRDT- 2015/08/08 06:00 PHST- 2015/08/08 06:00 [entrez] PHST- 2015/08/08 06:00 [pubmed] PHST- 2016/12/31 06:00 [medline] AID - 10.1080/07315724.2015.1014120 [doi] PST - ppublish SO - J Am Coll Nutr. 2016;35(3):271-83. doi: 10.1080/07315724.2015.1014120. Epub 2015 Aug 7.