PMID- 26252455 OWN - NLM STAT- MEDLINE DCOM- 20160510 LR - 20181202 IS - 1933-0693 (Electronic) IS - 0022-3085 (Linking) VI - 124 IP - 1 DP - 2016 Jan TI - Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies. PG - 77-89 LID - 10.3171/2015.1.JNS14681 [doi] AB - OBJECT The object of this study was to perform a systematic review, according to Preferred Reporting Items of Systematic reviews and Meta-Analyses (PRISMA) and Agency for Healthcare Research and Quality (AHRQ) guidelines, of the clinical efficacy and adverse effect profile of dorsal anterior cingulotomy compared with anterior capsulotomy for the treatment of severe, refractory obsessive-compulsive disorder (OCD). METHODS The authors included studies comparing objective clinical measures before and after cingulotomy or capsulotomy (surgical and radiosurgical) in patients with OCD. Only papers reporting the most current follow-up data for each group of investigators were included. Studies reporting results on patients undergoing one or more procedures other than cingulotomy or capsulotomy were excluded. Case reports and studies with a mean follow-up shorter than 12 months were excluded. Clinical response was defined in terms of a change in the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score. The authors searched MEDLINE, PubMed, PsycINFO, Scopus, and Web of Knowledge through October 2013. English and non-English articles and abstracts were reviewed. RESULTS Ten studies involving 193 participants evaluated the length of follow-up, change in the Y-BOCS score, and postoperative adverse events (AEs) after cingulotomy (n = 2 studies, n = 81 participants) or capsulotomy (n = 8 studies, n = 112 participants). The average time to the last follow-up was 47 months for cingulotomy and 60 months for capsulotomy. The mean reduction in the Y-BOCS score at 12 months' follow-up was 37% for cingulotomy and 55% for capsulotomy. At the last follow-up, the mean reduction in Y-BOCS score was 37% for cingulotomy and 57% for capsulotomy. The average full response rate to cingulotomy at the last follow-up was 41% (range 38%-47%, n = 2 studies, n = 51 participants), and to capsulotomy was 54% (range 37%-80%, n = 5 studies, n = 50 participants). The rate of transient AEs was 14.3% across cingulotomy studies (n = 116 procedures) and 56.2% across capsulotomy studies (n = 112 procedures). The rate of serious or permanent AEs was 5.2% across cingulotomy studies and 21.4% across capsulotomy studies. CONCLUSIONS This systematic review of the literature supports the efficacy of both dorsal anterior cingulotomy and anterior capsulotomy in this highly treatment-refractory population. The observational nature of available data limits the ability to directly compare these procedures. Controlled or head-to-head studies are necessary to identify differences in efficacy or AEs and may lead to the individualization of treatment recommendations. FAU - Brown, Lauren T AU - Brown LT AD - Department of Neurological Surgery, Columbia University; and. FAU - Mikell, Charles B AU - Mikell CB AD - Department of Neurological Surgery, Columbia University; and. FAU - Youngerman, Brett E AU - Youngerman BE AD - Department of Neurological Surgery, Columbia University; and. FAU - Zhang, Yuan AU - Zhang Y AD - Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York. FAU - McKhann, Guy M 2nd AU - McKhann GM 2nd AD - Department of Neurological Surgery, Columbia University; and. FAU - Sheth, Sameer A AU - Sheth SA AD - Department of Neurological Surgery, Columbia University; and. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20150807 PL - United States TA - J Neurosurg JT - Journal of neurosurgery JID - 0253357 SB - IM MH - Drug Resistance MH - Gyrus Cinguli/*surgery MH - Humans MH - Internal Capsule/*surgery MH - Neurosurgical Procedures/adverse effects/*methods MH - Observational Studies as Topic MH - Obsessive-Compulsive Disorder/psychology/*surgery MH - Psychosurgery/adverse effects/*methods OTO - NOTNLM OT - AE = adverse event OT - AHRQ = Agency for Healthcare Research and Quality OT - CBTC = cortico-basal ganglia-thalamocortical OT - DBS = deep brain stimulation OT - LL = limbic leucotomy OT - MeSH = Medical Subject Headings OT - OCD = obsessive-compulsive disorder OT - OFC = orbitofrontal cortex OT - PRISMA = Preferred Reporting Items for Systematic reviews and Meta-Analyses OT - SCT = subcaudate tractotomy OT - Y-BOCS = Yale-Brown Obsessive Compulsive Scale OT - capsulotomy OT - cingulotomy OT - dACC = dorsal anterior cingulate cortex OT - functional neurosurgery OT - obsessive-compulsive disorder OT - psychiatric neurosurgery OT - stereotactic lesions EDAT- 2015/08/08 06:00 MHDA- 2016/05/11 06:00 CRDT- 2015/08/08 06:00 PHST- 2015/08/08 06:00 [entrez] PHST- 2015/08/08 06:00 [pubmed] PHST- 2016/05/11 06:00 [medline] AID - 10.3171/2015.1.JNS14681 [doi] PST - ppublish SO - J Neurosurg. 2016 Jan;124(1):77-89. doi: 10.3171/2015.1.JNS14681. Epub 2015 Aug 7.