PMID- 26252477
OWN - NLM
STAT- MEDLINE
DCOM- 20160523
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 8
DP  - 2015
TI  - Association between Changes in Muscle Quality with Exercise Training and Changes 
      in Cardiorespiratory Fitness Measures in Individuals with Type 2 Diabetes 
      Mellitus: Results from the HART-D Study.
PG  - e0135057
LID - 10.1371/journal.pone.0135057 [doi]
LID - e0135057
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with a reduction in 
      muscle quality. However, there is inadequate empirical evidence to determine 
      whether changes in muscle quality following exercise are associated with 
      improvement in cardiorespiratory fitness (CRF) in individuals with T2DM. The 
      objective of this study was to investigate the association between change in 
      muscle quality following a 9-month intervention of aerobic training (AT), 
      resistance training (RT) or a combination of both (ATRT) and cardiorespiratory 
      fitness (CRF) in individuals with T2DM. MATERIAL AND METHODS: A total of 196 
      participants were randomly assigned to a control, AT, RT, or combined ATRT for a 
      9-months intervention. The exposure variable was change in muscle quality [(Post: 
      leg muscle strength/leg muscle mass)-[(Pre: leg muscle strength/leg muscle 
      mass)]. Dependent variables were change in CRF measures including absolute and 
      relative VO2peak, and treadmill time to exhaustion (TTE) and estimated metabolic 
      equivalent task (METs). RESULTS: Continuous change in muscle quality was 
      independently associated with change in absolute (beta = 0.015; p = 0.019) and 
      relative (beta = 0.200; p = 0.005) VO2peak, and TTE (beta = 0.170; p = 0.043), but not 
      with estimated METs (p > 0.05). A significant trend was observed across tertiles 
      of change in muscle quality for changes in absolute (beta = 0.050; p = 0.005) and 
      relative (beta = 0.624; p = 0.002) VO2peak following 9 months of exercise training. 
      No such association was observed for change in TTE and estimated METs (p > 0.05). 
      DISCUSSION: The results from this ancillary study suggest that change in muscle 
      quality following exercise training is associated with a greater improvement in 
      CRF in individuals with T2DM. Given the effect RT has on increasing muscle 
      quality, especially as part of a recommended training program (ATRT), individuals 
      with T2DM should incorporate RT into their AT regimens to optimize CRF 
      improvement. TRIAL REGISTRATION: Clinicaltrials.gov NCT00458133.
FAU - Senechal, Martin
AU  - Senechal M
AD  - Faculty of Kinesiology, Fredericton, New Brunswick, Canada; University of New 
      Brunswick, Fredericton, New Brunswick, Canada.
FAU - Johannsen, Neil M
AU  - Johannsen NM
AD  - Department of Preventive Medicine, Pennington Biomedical Research Center, Baton 
      Rouge, Louisiana, United States of America; The Louisiana State University, Baton 
      Rouge, Louisiana, United States of America.
FAU - Swift, Damon L
AU  - Swift DL
AD  - Department of Kinesiology, East Carolina University, Greenville, North Carolina, 
      United States of America; Center for Health Disparities, East Carolina 
      University, Greenville, North Carolina, United States of America.
FAU - Earnest, Conrad P
AU  - Earnest CP
AD  - Department of Preventive Medicine, Pennington Biomedical Research Center, Baton 
      Rouge, Louisiana, United States of America.
FAU - Lavie, Carl J
AU  - Lavie CJ
AD  - John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University 
      of Queensland School of Medicine, New Orleans, Louisiana, United States of 
      America.
FAU - Blair, Steven N
AU  - Blair SN
AD  - University of South Carolina, Columbia, South Carolina, United States of America.
FAU - Church, Timothy S
AU  - Church TS
AD  - Department of Preventive Medicine, Pennington Biomedical Research Center, Baton 
      Rouge, Louisiana, United States of America.
LA  - eng
SI  - ClinicalTrials.gov/NCT00458133
GR  - R01 DK068298/DK/NIDDK NIH HHS/United States
GR  - DK068298/DK/NIDDK NIH HHS/United States
GR  - CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150807
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anthropometry
MH  - Body Composition
MH  - *Cardiovascular System
MH  - Diabetes Mellitus, Type 2/physiopathology/*therapy
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Exercise Therapy
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Oxygen Consumption
MH  - Physical Fitness/*physiology
MH  - Resistance Training
MH  - Sedentary Behavior
PMC - PMC4529285
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/08/08 06:00
MHDA- 2016/05/24 06:00
PMCR- 2015/08/07
CRDT- 2015/08/08 06:00
PHST- 2015/03/14 00:00 [received]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/08/08 06:00 [entrez]
PHST- 2015/08/08 06:00 [pubmed]
PHST- 2016/05/24 06:00 [medline]
PHST- 2015/08/07 00:00 [pmc-release]
AID - PONE-D-15-11229 [pii]
AID - 10.1371/journal.pone.0135057 [doi]
PST - epublish
SO  - PLoS One. 2015 Aug 7;10(8):e0135057. doi: 10.1371/journal.pone.0135057. 
      eCollection 2015.