PMID- 26253933
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20150925
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 150
DP  - 2015 Sep
TI  - Whole-body vibration improves the anti-inflammatory status in elderly subjects 
      through toll-like receptor 2 and 4 signaling pathways.
PG  - 12-9
LID - S0047-6374(15)30006-3 [pii]
LID - 10.1016/j.mad.2015.08.002 [doi]
AB  - Regular physical exercise has anti-inflammatory effects in elderly subjects. Yet, 
      the inflammatory responses after whole body vibration (WBV) training, a popular 
      exercise paradigm for the elderly, remain to be elucidated. This study assessed 
      the effects of WBV training on the inflammatory response associated with 
      toll-like receptors (TLRs) signaling pathways. Twenty-eight subjects were 
      randomized to a training group (TG) or a control group (CG). TG followed an 
      8-week WBV training program. Blood samples were obtained before and after the 
      training period in both groups. Peripheral blood mononuclear cells were isolated, 
      and mRNA and protein levels of makers involved in the TLR2/TLR4 myeloid 
      differentiation primary response gen 88 (MyD88) and TIR domain-containing adaptor 
      inducing interferon (TRIF)-dependent pathways were analyzed. Plasma TNFalpha and 
      C-reactive protein levels were also assessed. The WBV program reduced protein 
      expression of TLR2, TLR4, MyD88, p65, TRIF and heat shock protein (HSP) 60, while 
      HSP70 content increased. IL-10 mRNA level and protein concentration were 
      upregulated, and TNFalpha protein content decreased, after WBV training. Plasma 
      concentration of C-reactive protein and TNFalpha decreased in the TG. The current 
      data suggest WBV may improve the anti-inflammatory status of elderly subjects 
      through an attenuation of MyD88- and TRIF-dependent TLRs signaling pathways.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Rodriguez-Miguelez, Paula
AU  - Rodriguez-Miguelez P
AD  - Division of Clinical Translational Science, Georgia Prevention Institute, 
      Department of Pediatrics, Georgia Regents University, USA.
FAU - Fernandez-Gonzalo, Rodrigo
AU  - Fernandez-Gonzalo R
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Collado, Pilar S
AU  - Collado PS
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
FAU - Almar, Mar
AU  - Almar M
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
FAU - Martinez-Florez, Susana
AU  - Martinez-Florez S
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
FAU - de Paz, Jose A
AU  - de Paz JA
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
FAU - Gonzalez-Gallego, Javier
AU  - Gonzalez-Gallego J
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
FAU - Cuevas, Maria J
AU  - Cuevas MJ
AD  - Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain. Electronic 
      address: mj.cuevas@unileon.es.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150804
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Inflammation Mediators)
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Aged
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - *Signal Transduction
MH  - Toll-Like Receptor 2/*metabolism
MH  - Toll-Like Receptor 4/*metabolism
MH  - *Vibration
OTO - NOTNLM
OT  - Elderly
OT  - Heat shock proteins
OT  - Inflammation
OT  - Toll-like receptors
OT  - Whole body vibration
EDAT- 2015/08/09 06:00
MHDA- 2016/07/01 06:00
CRDT- 2015/08/09 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/07/21 00:00 [revised]
PHST- 2015/08/02 00:00 [accepted]
PHST- 2015/08/09 06:00 [entrez]
PHST- 2015/08/09 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
AID - S0047-6374(15)30006-3 [pii]
AID - 10.1016/j.mad.2015.08.002 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2015 Sep;150:12-9. doi: 10.1016/j.mad.2015.08.002. Epub 2015 Aug 
      4.