PMID- 26254058
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20231112
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Aug
TI  - Molecular network of neuronal autophagy in the pathophysiology and treatment of 
      depression.
PG  - 427-34
LID - 10.1007/s12264-015-1548-2 [doi]
AB  - Major depressive disorder (MDD) is a complicated multifactorial induced disease, 
      characterized by depressed mood, anhedonia, fatigue, and altered cognitive 
      function. Recently, many studies have shown that antidepressants regulate 
      autophagy. In fact, autophagy, a conserved lysosomal degradation pathway, is 
      essential for the central nervous system. Dysregulation of autophagic pathways, 
      such as the mammalian target of rapamycin (mTOR) signaling pathway and the beclin 
      pathway, has been studied in neurodegenerative diseases. However, autophagy in 
      MDD has not been fully studied. Here, we discuss whether the dysregulation of 
      autophagy contributes to the pathophysiology and treatment of MDD and summarize 
      the current evidence that shows the involvement of autophagy in MDD.
FAU - Jia, Jack
AU  - Jia J
AD  - Sbarro Institute for Cancer Research and Molecular Medicine, Center of 
      Biotechnology, College of Science and Technology, Temple University, 
      Philadelphia, PA, USA.
FAU - Le, Weidong
AU  - Le W
LA  - eng
PT  - Journal Article
DEP - 20150808
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Antidepressive Agents)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - *Autophagy
MH  - Brain/*physiopathology
MH  - Depressive Disorder, Major/drug therapy/*metabolism/*physiopathology
MH  - Humans
MH  - Neurodegenerative Diseases/metabolism/physiopathology
MH  - Neurons/*physiology
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC5563719
EDAT- 2015/08/09 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/08/01
CRDT- 2015/08/09 06:00
PHST- 2015/04/30 00:00 [received]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/08/09 06:00 [entrez]
PHST- 2015/08/09 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 1548 [pii]
AID - 10.1007/s12264-015-1548-2 [doi]
PST - ppublish
SO  - Neurosci Bull. 2015 Aug;31(4):427-34. doi: 10.1007/s12264-015-1548-2. Epub 2015 
      Aug 8.