PMID- 26255090
OWN - NLM
STAT- MEDLINE
DCOM- 20160816
LR  - 20191210
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 221
IP  - 1
DP  - 2016 Jan
TI  - The role of nucleotide-binding oligomerization domain 1 during cytokine 
      production by macrophages in response to Mycobacterium tuberculosis infection.
PG  - 70-5
LID - S0171-2985(15)30039-5 [pii]
LID - 10.1016/j.imbio.2015.07.020 [doi]
AB  - Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of 
      death worldwide. Recognition of this pathogen is crucial for the activation of 
      innate and adaptive immune responses. Nucleotide-binding oligomerization domain 
      (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of 
      bacterial peptidoglycan. Nod2 is critical for the initiation of the host immune 
      response against M. tuberculosis infection, however the role of Nod1 remains 
      largely unknown. We investigated the role of Nod1 with respect to cytokine 
      production by bone marrow-derived macrophages (BMDMs) in response to M. 
      tuberculosis infection. Production of proinflammatory cytokines, such as IL-6, 
      TNF-alpha, and IL-1beta were induced in BMDMs; cytokine levels were not affected by a 
      deficiency in Nod1. Activation of NF-kappaB and MAPKs was also comparable between 
      wild-type and Nod1-deficient BMDMs. Levels of IL-6 and IL-1beta were reduced in 
      Nod1/Nod2 double-deficient BMDMs to a greater extent than in Nod2-deficient 
      cells. Furthermore, when signaling of Toll-like receptors (TLRs) was inhibited by 
      lipopolysaccharide pre-treatment, cytokine production was diminished in 
      Nod1-deficient BMDMs. Our results indicate that Nod1 cooperates with Nod2 or TLRs 
      to produce cytokines in macrophages in response to M. tuberculosis infection.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Lee, Jun-Young
AU  - Lee JY
AD  - Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National 
      University, Gwangju 500-757, Republic of Korea.
FAU - Hwang, Eun-Ha
AU  - Hwang EH
AD  - Department of Biochemistry, College of Medicine, Konyang University, Daejeon 
      302-718, Republic of Korea.
FAU - Kim, Dong-Jae
AU  - Kim DJ
AD  - Department of Biochemistry, College of Medicine, Konyang University, Daejeon 
      302-718, Republic of Korea.
FAU - Oh, Sang-Muk
AU  - Oh SM
AD  - Department of Biochemistry, College of Medicine, Konyang University, Daejeon 
      302-718, Republic of Korea.
FAU - Lee, Kyung-Bok
AU  - Lee KB
AD  - Department of Biochemistry, College of Medicine, Konyang University, Daejeon 
      302-718, Republic of Korea.
FAU - Shin, Sung Jae
AU  - Shin SJ
AD  - Department of Microbiology, Institute for Immunology and Immunological Diseases, 
      Brain Korea 21 PLUS Project for Medical Science, Yonsei University of Medicine, 
      Seoul 129-740, Republic of Korea. Electronic address: sjshin@yuhs.ac.
FAU - Park, Jong-Hwan
AU  - Park JH
AD  - Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National 
      University, Gwangju 500-757, Republic of Korea. Electronic address: 
      jonpark@jnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150726
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Nod1 Signaling Adaptor Protein)
RN  - 0 (Nod1 protein, mouse)
RN  - 0 (Nod2 Signaling Adaptor Protein)
RN  - 0 (Nod2 protein, mouse)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin-6, mouse)
RN  - EC 2.7.11.24 (Mapk1 protein, mouse)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation
MH  - Interleukin-1beta/genetics/immunology
MH  - Interleukin-6/genetics/immunology
MH  - Lipopolysaccharides/pharmacology
MH  - MAP Kinase Kinase 4/genetics/immunology
MH  - Macrophages/drug effects/*immunology/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mitogen-Activated Protein Kinase 1/genetics/immunology
MH  - Mitogen-Activated Protein Kinase 3/genetics/immunology
MH  - Mycobacterium tuberculosis/*immunology
MH  - NF-kappa B/genetics/immunology
MH  - Nod1 Signaling Adaptor Protein/deficiency/genetics/*immunology
MH  - Nod2 Signaling Adaptor Protein/deficiency/genetics/*immunology
MH  - Primary Cell Culture
MH  - Signal Transduction
MH  - Toll-Like Receptors/genetics/*immunology
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
MH  - p38 Mitogen-Activated Protein Kinases/genetics/immunology
OTO - NOTNLM
OT  - Cytokines
OT  - Innate immune response
OT  - Macrophages
OT  - Nod1
EDAT- 2015/08/10 06:00
MHDA- 2016/08/17 06:00
CRDT- 2015/08/10 06:00
PHST- 2015/04/02 00:00 [received]
PHST- 2015/07/14 00:00 [revised]
PHST- 2015/07/23 00:00 [accepted]
PHST- 2015/08/10 06:00 [entrez]
PHST- 2015/08/10 06:00 [pubmed]
PHST- 2016/08/17 06:00 [medline]
AID - S0171-2985(15)30039-5 [pii]
AID - 10.1016/j.imbio.2015.07.020 [doi]
PST - ppublish
SO  - Immunobiology. 2016 Jan;221(1):70-5. doi: 10.1016/j.imbio.2015.07.020. Epub 2015 
      Jul 26.